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Tbio
TNFRSF13C
Tumor necrosis factor receptor superfamily member 13C

Protein Summary
Description
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291232
  • ENSP00000291232
  • ENSG00000159958

Symbol
  • BAFFR
  • BR3
  • BAFFR
  • CD268
  • CVID4
  • BAFF-R
  • BROMIX
  • prolixin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.64
biological term
0.62
PubMedID
0.61
transcription factor
0.61
gene perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.48   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 569   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.48   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 569   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
7.9
basophil count
1
1
1
4.9
diet measurement
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
7.9
basophil count
1
4.9
diet measurement
1
0.9
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 13C
VGNC:12933
104003794
Mouse
MGI:1919299
72049
Rat
RGD:1560810
500910
Dog
TNF receptor superfamily member 13C
VGNC:54377
607785
Horse
TNF receptor superfamily member 13C
VGNC:24366
100070724
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 13C
Mouse
Rat
Dog
TNF receptor superfamily member 13C
Horse
TNF receptor superfamily member 13C
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96RJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Reactome
TNFR2 non-canonical NF-kB pathway
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFR2 non-canonical NF-kB pathway
Protein-Protein Interactions (161)
1 – 10 of 161
TNFSF13B
Tclin
Novelty: 0.00069885
Score: 0.997
Data Source: Reactome,STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.988
Data Source: Reactome,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.961
Data Source: Reactome,STRINGDB
CD40LG
Tbio
Novelty: 0.00032058
Score: 0.957
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.956
Data Source: STRINGDB
MAP3K14
Tchem
Family: Kinase
Novelty: 0.0350173
Score: 0.944
Data Source: Reactome,STRINGDB
LTBR
Tbio
Novelty: 0.003823
Score: 0.941
Data Source: STRINGDB
TNFSF12
Tbio
Novelty: 0.00298471
Score: 0.941
Data Source: STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
Score: 0.941
Data Source: Reactome,STRINGDB
TNFRSF12A
Tbio
Novelty: 0.00550274
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  335.48

PubMed score by year
PubTator Score  152.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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