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Tclin
TAAR1
Trace amine-associated receptor 1

Protein Summary
Description
Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275216
  • ENSP00000275216
  • ENSG00000146399

Symbol
  • TA1
  • TAR1
  • TRAR1
  • TA1
  • TAR1
  • TRAR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.78
gene perturbation
0.71
cell line
0.61
protein domain
0.58
chemical
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.56   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.56   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (70)
Protein-Protein Interactions (150)
AVPR2
Tclin
Family:  GPCR
Novelty:  0.0009139
Score:  0.928
Data Source:  STRINGDB
GIPR
Tchem
Family:  GPCR
Novelty:  0.00961809
Score:  0.928
Data Source:  STRINGDB
TSHR
Tclin
Family:  GPCR
Novelty:  0.00074972
Score:  0.926
Data Source:  STRINGDB
CALCRL
Tclin
Family:  GPCR
Novelty:  0.00568602
Score:  0.923
Data Source:  STRINGDB
GNG12
Tbio
Novelty:  0.12611933
Score:  0.917
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.917
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.915
Data Source:  STRINGDB
GNB5
Tbio
Novelty:  0.0067714
Score:  0.915
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.915
Data Source:  STRINGDB
SCT
Tbio
Novelty:  0.00070278
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of smell
1
1
1
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of smell
1
63.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trace amine associated receptor 1
VGNC:3718
493908
Macaque
trace amine associated receptor 1
708944
Mouse
MGI:2148258
111174
Rat
RGD:621621
113914
Horse
trace amine associated receptor 1
VGNC:23835
106780887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trace amine associated receptor 1
Macaque
trace amine associated receptor 1
Mouse
Rat
Horse
trace amine associated receptor 1
Publication Statistics
PubMed Score 628.56
PubMed score by year
PubTator Score 172.02
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title