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Tbio
TAAR6
Trace amine-associated receptor 6

Protein Summary
Description
Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275198
  • ENSP00000275198
  • ENSG00000146383

Symbol
  • TA4
  • TAR4
  • TRAR4
  • TA4
  • TAR4
  • TAR6
  • TRAR4
  • taR-4
  • taR-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.54
phenotype
0.5
biological process
0.49
cell line
0.48
biological term
0.41


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.22   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.22   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
trace amine associated receptor 6
709418
Mouse
MGI:2685074
215855
Rat
RGD:631384
294124
Opossum
trace amine-associated receptor 8a-like
100031169
Species
Name
OMA
EggNOG
Inparanoid
Macaque
trace amine associated receptor 6
Mouse
Rat
Opossum
trace amine-associated receptor 8a-like
Pathways (8)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (143)
1 – 10 of 143
GIPR
Tchem
Family: GPCR
Novelty: 0.00961809
Score: 0.921
Data Source: STRINGDB
SCT
Tbio
Novelty: 0.00070278
Score: 0.919
Data Source: STRINGDB
TAAR8
Tbio
Family: GPCR
Novelty: 0.00862757
Score: 0.919
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.916
Data Source: STRINGDB
GNG7
Tbio
Novelty: 0.08478455
Score: 0.916
Data Source: STRINGDB
GNB2
Tbio
Novelty: 0.08682553
Score: 0.915
Data Source: STRINGDB
GNB4
Tbio
Novelty: 0.08250797
Score: 0.915
Data Source: STRINGDB
GPR39
Tchem
Family: GPCR
Novelty: 0.01244607
Score: 0.915
Data Source: STRINGDB
GNG8
Tdark
Novelty: 0.00590503
Score: 0.915
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  171.22

PubMed score by year
PubTator Score  76.66

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer