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Tclin
NR1H4
Bile acid receptor

Protein Summary
Description
Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response (PubMed:10334992, PubMed:10334993, PubMed:21383957, PubMed:22820415). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcription ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000188403
  • ENSP00000188403
  • ENSG00000012504
  • ENST00000392986
  • ENSP00000376712
  • ENST00000548884
  • ENSP00000448506
  • ENST00000549996
  • ENSP00000448978
  • ENST00000551379
  • ENSP00000447149
  • ENST00000648861
  • ENSP00000496908

Symbol
  • BAR
  • FXR
  • HRR1
  • RIP14
  • BAR
  • FXR
  • HRR1
  • HRR-1
  • PFIC5
  • RIP14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.94
protein domain
0.85
chemical
0.81
gene perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2260.34   (req: < 5)
Gene RIFs: 240   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2260.34   (req: >= 5)
Gene RIFs: 240   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 76
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 333
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3