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Tclin
NR1H4
Bile acid receptor

Protein Summary
Description
Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response (PubMed:10334992, PubMed:10334993, PubMed:21383957, PubMed:22820415). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcription ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000188403
  • ENSP00000188403
  • ENSG00000012504
  • ENST00000392986
  • ENSP00000376712
  • ENST00000548884
  • ENSP00000448506
  • ENST00000549996
  • ENSP00000448978
  • ENST00000551379
  • ENSP00000447149
  • ENST00000648861
  • ENSP00000496908

Symbol
  • BAR
  • FXR
  • HRR1
  • RIP14
  • BAR
  • FXR
  • HRR1
  • HRR-1
  • PFIC5
  • RIP14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.94
protein domain
0.85
chemical
0.81
gene perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1799.92   (req: < 5)
Gene RIFs: 190   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1799.92   (req: >= 5)
Gene RIFs: 190   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 76
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 152
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
98.2
testosterone measurement
3
1
3
95.4
C-reactive protein measurement
1
1
1
76.7
low density lipoprotein cholesterol measurement
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
98.2
testosterone measurement
3
95.4
C-reactive protein measurement
1
76.7
low density lipoprotein cholesterol measurement
1
6.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group H member 4
VGNC:5505
452162
Macaque
nuclear receptor subfamily 1 group H member 4
695618
Mouse
MGI:1352464
20186
Rat
RGD:628831
60351
Dog
nuclear receptor subfamily 1 group H member 4
VGNC:43944
612928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group H member 4
Macaque
nuclear receptor subfamily 1 group H member 4
Mouse
Rat
Dog
nuclear receptor subfamily 1 group H member 4
Protein Structure (73 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96RI1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 73
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Endogenous sterols
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Gene expression (Transcription)
Gene Ontology Terms (80)
Items per page:
10
1 – 10 of 23
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (240)
1 – 10 of 240
RXRB
Tclin
Family: NR
Novelty: 0.01503977
p_int: 0.999997526
p_ni: 0.000002427
p_wrong: 4.6e-8
Score: 0.978
Data Source: BioPlex,STRINGDB
CYP7A1
Tbio
Family: Enzyme
Novelty: 0.00148194
Score: 0.996
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.994
Data Source: Reactome,STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.992
Data Source: Reactome,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.988
Data Source: STRINGDB
NR0B2
Tchem
Family: NR
Novelty: 0.0009861
Score: 0.986
Data Source: STRINGDB
FABP6
Tbio
Novelty: 0.00671588
Score: 0.973
Data Source: STRINGDB
ABCB11
Tchem
Family: Transporter
Novelty: 0.00097529
Score: 0.955
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.953
Data Source: STRINGDB
RXRG
Tclin
Family: NR
Novelty: 0.01646377
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  1799.92

PubMed score by year
PubTator Score  782.54

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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