Tchem F2RL3 Proteinase-activated receptor 4

Protein Summary

Description

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q96RI0
• O76067
• Q6DK42
• PAR-4

Gene Name

• F2RL3

Ensembl ID

• ENST00000248076
• ENSP00000248076
• ENSG00000127533

Symbol

• PAR4
• PAR4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.85
gene perturbation	0.78
microRNA	0.7
biological term	0.66
tissue	0.62

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Proteinase-activated Receptor / Proteinase-activated Receptor 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.96   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 369   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.96   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 704

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0