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Tchem
F2RL3
Proteinase-activated receptor 4

Protein Summary
Description
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248076
  • ENSP00000248076
  • ENSG00000127533

Symbol
  • PAR4
  • PAR4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.85
gene perturbation
0.78
microRNA
0.7
biological term
0.66
tissue
0.62


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.71   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.71   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 696
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F2R like thrombin or trypsin receptor 3
VGNC:14841
455829
Mouse
MGI:1298207
14065
Rat
RGD:620872
116498
Dog
F2R like thrombin or trypsin receptor 3
VGNC:40550
484846
Horse
F2R like thrombin or trypsin receptor 3 [Source:HGNC Symbol;Acc:HGNC:3540]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F2R like thrombin or trypsin receptor 3
Mouse
Rat
Dog
F2R like thrombin or trypsin receptor 3
Horse
F2R like thrombin or trypsin receptor 3 [Source:HGNC Symbol;Acc:HGNC:3540]
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96RI0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Hemostasis
Protein-Protein Interactions (193)
1 – 10 of 193
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.987
Data Source:  Reactome,STRINGDB
GNG12
Tbio
Novelty:  0.12611933
Score:  0.949
Data Source:  STRINGDB
F2RL2
Tbio
Family:  GPCR
Novelty:  0.2305357
Score:  0.943
Data Source:  Reactome,STRINGDB
GNA12
Tbio
Novelty:  0.06310884
Score:  0.929
Data Source:  Reactome,STRINGDB
UTS2B
Tbio
Novelty:  0.04307669
Score:  0.921
Data Source:  STRINGDB
FFAR4
Tchem
Family:  GPCR
Novelty:  0.00439747
Score:  0.92
Data Source:  STRINGDB
TBXA2R
Tclin
Family:  GPCR
Novelty:  0.00571066
Score:  0.916
Data Source:  STRINGDB
F2R
Tclin
Family:  GPCR
Novelty:  0.00080964
Score:  0.915
Data Source:  Reactome,STRINGDB
HTR2B
Tclin
Family:  GPCR
Novelty:  0.00237051
Score:  0.915
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.914
Data Source:  STRINGDB
Publication Statistics
PubMed Score  60.71

PubMed score by year
PubTator Score  168.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer