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Tchem
PASK
PAS domain-containing serine/threonine-protein kinase

Protein Summary
Description
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. D ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234040
  • ENSP00000234040
  • ENSG00000115687
  • ENST00000358649
  • ENSP00000351475
  • ENST00000403638
  • ENSP00000384438
  • ENST00000405260
  • ENSP00000384016
  • ENST00000544142
  • ENSP00000441374

Symbol
  • KIAA0135
  • STK37
  • PASKIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
histone modification site profile
0.89
protein domain
0.85
transcription factor binding site profile
0.7
cell line
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.16   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.16   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (88)
GTF3C4
Tdark
Family:  Epigenetic
Novelty:  0.28198123
p_int:  0.999333121
p_ni:  0.000666879
Data Source:  BioPlex
TRIM41
Tbio
Family:  Enzyme
Novelty:  0.17238173
p_int:  0.997531891
p_ni:  0.002468109
Score:  0.152
Data Source:  BioPlex,STRINGDB
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.993810971
p_ni:  0.006189029
Data Source:  BioPlex
CCL26
Tbio
Novelty:  0.00556498
p_int:  0.991735715
p_ni:  0.008264285
Data Source:  BioPlex
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.989022775
p_ni:  0.010977225
Data Source:  BioPlex
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.978531607
p_ni:  0.021468393
Data Source:  BioPlex
WNT4
Tbio
Novelty:  0.00276803
p_int:  0.969582742
p_ni:  0.030417258
Score:  0.223
Data Source:  BioPlex,STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
p_int:  0.958068458
p_ni:  0.041931542
Score:  0.42
Data Source:  BioPlex,STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.954835903
p_ni:  0.045164097
Data Source:  BioPlex
ZNF550
Tdark
Family:  TF
Novelty:  18
p_int:  0.941669525
p_ni:  0.058330475
Score:  0.243
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
75.9
mean reticulocyte volume
1
1
1
65.3
BMI-adjusted hip circumference
2
4
4
64.2
IGF-1 measurement
1
1
1
44.2
hip circumference
1
2
2
39.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
75.9
mean reticulocyte volume
1
65.3
BMI-adjusted hip circumference
4
64.2
IGF-1 measurement
1
44.2
hip circumference
2
39.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PAS domain containing serine/threonine kinase
VGNC:2746
460077
Macaque
PAS domain containing serine/threonine kinase
700457
Mouse
MGI:2155936
269224
Rat
RGD:1306146
301617
Dog
PAS domain containing serine/threonine kinase
VGNC:44270
609502
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PAS domain containing serine/threonine kinase
Macaque
PAS domain containing serine/threonine kinase
Mouse
Rat
Dog
PAS domain containing serine/threonine kinase
Publication Statistics
PubMed Score 8.16
PubMed score by year
PubTator Score 31.51
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title