Tchem PASK PAS domain-containing serine/threonine-protein kinase

Protein Summary

Description

Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q96RG2
• G5E9F1
• Q05BE4
• Q68DY3
• Q6GSJ5
• Q86XH6
• Q99763
• Q9UFR7
• PAS-kinase

Gene Name

• PASK

Ensembl ID

• ENST00000234040
• ENSP00000234040
• ENSG00000115687
• ENST00000358649
• ENSP00000351475
• ENST00000403638
• ENSP00000384438
• ENST00000405260
• ENSP00000384016
• ENST00000544142
• ENSP00000441374

Symbol

• KIAA0135
• STK37
• PASKIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
histone modification site profile	0.89
protein domain	0.85
transcription factor binding site profile	0.7
cell line	0.67

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Pas Domain-containing Serine/threonine-protein Kinase

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camkl Family / Pask Subfamily / Pas Domain-containing Serine/threonine-protein Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.85   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.85   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0