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Tbio
ZNF300
Zinc finger protein 300

Protein Summary
Description
Has a transcriptional repressor activity. The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274599
  • ENSP00000274599
  • ENSG00000145908
  • ENST00000418587
  • ENSP00000392593
  • ENST00000446148
  • ENSP00000397178
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
cell type or tissue
0.69
protein domain
0.58
tissue
0.5
microRNA
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.24   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.24   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
85.4
1
1
0
1.2
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
85.4
0
1.2
74.1
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 300
VGNC:13618
471700
Macaque
zinc finger protein 300
712991
Dog
zinc finger protein 300
100684596
Horse
zinc finger protein 300 [Source:HGNC Symbol;Acc:HGNC:13091]
Cow
zinc finger protein 300
VGNC:49995
524256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 300
Macaque
zinc finger protein 300
Dog
zinc finger protein 300
Horse
zinc finger protein 300 [Source:HGNC Symbol;Acc:HGNC:13091]
Cow
zinc finger protein 300
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96RE9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (18)
1 – 10 of 18
SLC9A8
Tbio
Family: Transporter
Novelty: 0.03305341
p_int: 0.999502024
p_ni: 1.1e-8
p_wrong: 0.000497965
Data Source: BioPlex
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.921
Data Source: STRINGDB
IRGM
Tbio
Family: Enzyme
Novelty: 0.0065731
Score: 0.756
Data Source: STRINGDB
BCORL1
Tbio
Novelty: 0.03899646
Score: 0.514
Data Source: STRINGDB
NKX3-2
Tbio
Family: TF
Novelty: 0.01804711
Score: 0.497
Data Source: STRINGDB
NKX2-2
Tbio
Family: TF
Novelty: 0.00608835
Score: 0.445
Data Source: STRINGDB
NYAP1
Tdark
Family: Enzyme
Novelty: 0.57209235
Score: 0.439
Data Source: STRINGDB
ETV2
Tbio
Family: TF
Novelty: 0.01989759
Score: 0.428
Data Source: STRINGDB
NWD1
Tdark
Novelty: 0.28220226
Score: 0.423
Data Source: STRINGDB
ETV3
Tbio
Family: TF
Novelty: 0.05215391
Score: 0.416
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.24

PubMed score by year
PubTator Score  9.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer