Tbio NACC1 Nucleus accumbens-associated protein 1

Protein Summary

Description

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q96RE7
• NAC-1

Gene Name

• NACC1

Ensembl ID

• ENST00000292431
• ENSP00000292431
• ENSG00000160877

Symbol

• BTBD14B
• NAC1
• NAC1
• BEND8
• NAC-1
• NECFM
• BTBD30
• BTBD14B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.9
interacting protein	0.87
histone modification site profile	0.71
cell type or tissue	0.67
transcription factor binding site profile	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.97   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 271   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.97   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0