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Tbio
PANX1
Pannexin-1

Protein Summary
Description
Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227638
  • ENSP00000227638
  • ENSG00000110218
  • ENST00000436171
  • ENSP00000411461

Symbol
  • MRS1
  • PX1
  • MRS1
  • UNQ2529
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
molecular function
0.97
gene perturbation
0.86
kinase perturbation
0.81
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.73   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.73   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (9)
Electric Transmission Across Gap Junctions (R-HSA-112303)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Electric Transmission Across Gap Junctions
Reactome
Immune System
Reactome
Inflammasomes
Reactome
Innate Immune System
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Electric Transmission Across Gap Junctions
Immune System
Inflammasomes
Innate Immune System
Neuronal System
Gene Ontology Terms (25)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (90)
1 – 10 of 90
C4orf3
Tbio
Novelty: 0.00732312
p_int: 0.999930551
p_ni: 0.000061682
p_wrong: 0.000007766
Data Source: BioPlex
HTR3A
Tclin
Family: IC
Novelty: 0.00035394
p_int: 0.999928551
p_ni: 0.000059599
p_wrong: 0.00001185
Score: 0.241
Data Source: BioPlex,STRINGDB
GRPR
Tchem
Family: GPCR
Novelty: 0.00322431
p_int: 0.910188216
p_ni: 0.000909061
p_wrong: 0.088902723
Score: 0.175
Data Source: BioPlex,STRINGDB
C5AR2
Tbio
Family: GPCR
Novelty: 0.01354267
p_int: 0.818422131
p_ni: 0.000877435
p_wrong: 0.180700434
Score: 0.179
Data Source: BioPlex,STRINGDB
P2RX7
Tchem
Family: IC
Novelty: 0.00096326
Score: 0.992
Data Source: Reactome,STRINGDB
PANX2
Tbio
Family: IC
Novelty: 0.00929804
Score: 0.93
Data Source: Reactome,STRINGDB
GJA1
Tbio
Novelty: 0.00023576
Score: 0.824
Data Source: STRINGDB
P2RX1
Tchem
Family: IC
Novelty: 0.00376724
Score: 0.812
Data Source: STRINGDB
P2RX4
Tchem
Family: IC
Novelty: 0.00292374
Score: 0.792
Data Source: STRINGDB
GJB1
Tbio
Novelty: 0.00115116
Score: 0.785
Data Source: STRINGDB
Publication Statistics
PubMed Score  506.73

PubMed score by year
PubTator Score  267.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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