Tbio PANX1 Pannexin-1

Protein Summary

Description

Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96RD7
• O75968
• Q543A0
• Q6UW26
• Q96AM9
• Q96L77
• Q96RS5

Gene Name

• PANX1

Ensembl ID

• ENST00000227638
• ENSP00000227638
• ENSG00000110218
• ENST00000436171
• ENSP00000411461

Symbol

• MRS1
• PX1
• MRS1
• UNQ2529

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
molecular function	0.97
gene perturbation	0.86
kinase perturbation	0.81
transcription factor binding site profile	0.76

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 772.03   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 231   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 772.03   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (90)

Explore Interacting Targets

1 – 10 of 90

• See Interactions on String-DB

C4orf3

Tbio

Novelty:  0.05950373

p_int:  0.999930551

p_ni:  0.000061682

p_wrong:  0.000007766

Data Source:  BioPlex

HTR3A

Tclin

Family:  IC

Novelty:  0.00217443

p_int:  0.999928551

p_ni:  0.000059599

p_wrong:  0.00001185

Score:  0.241

Data Source:  BioPlex,STRINGDB

GRPR

Tchem

Family:  GPCR

Novelty:  0.00282511

p_int:  0.910188216

p_ni:  0.000909061

p_wrong:  0.088902723

Score:  0.175

Data Source:  BioPlex,STRINGDB

C5AR2

Tbio

Family:  GPCR

Novelty:  0.01193736

p_int:  0.818422131

p_ni:  0.000877435

p_wrong:  0.180700434

Score:  0.179

Data Source:  BioPlex,STRINGDB

P2RX7

Tchem

Family:  IC

Novelty:  0.00090502

Score:  0.992

Data Source:  Reactome,STRINGDB

PANX2

Tbio

Family:  IC

Novelty:  0.00620748

Score:  0.93

Data Source:  Reactome,STRINGDB

GJA1

Tbio

Novelty:  0.00021332

Score:  0.824

Data Source:  STRINGDB

P2RX1

Tchem

Family:  IC

Novelty:  0.00286826

Score:  0.812

Data Source:  STRINGDB

P2RX4

Tchem

Family:  IC

Novelty:  0.00242958

Score:  0.792

Data Source:  STRINGDB

GJB1

Tbio

Novelty:  0.00109019

Score:  0.785

Data Source:  STRINGDB

Pathways (9)

Reactome (8)

KEGG (1)

Electric Transmission Across Gap Junctions (R-HSA-112303)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Electric Transmission Across Gap Junctions	5 targets	R-HSA-112303
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Inflammasomes	20 targets	R-HSA-622312
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neuronal System	398 targets	R-HSA-112316

Name	Explore in Pharos	Explore in Source
Electric Transmission Across Gap Junctions	5 targets	R-HSA-112303
Immune System	2246 targets	R-HSA-168256
Inflammasomes	20 targets	R-HSA-622312
Innate Immune System	1188 targets	R-HSA-168249
Neuronal System	398 targets	R-HSA-112316

Gene Ontology Terms (25)

Functions (9)

Components (8)

Processes (8)

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Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
gap junction hemi-channel activity	Inferred from Direct Assay (IDA)	UniProtKB
signaling receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
calcium channel activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
leak channel activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
actin filament binding	Inferred from Electronic Annotation (IEA)	Ensembl
ion channel binding	Inferred from Electronic Annotation (IEA)	Ensembl
protease binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
scaffold protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
aspartate aminotransferase measurement	EFO_0004736	3	3	2	12.8	95.7
serum alanine aminotransferase measurement	EFO_0004735	3	2	2	15.6	94.7
Thyroid preparation use measurement	EFO_0009933	1	1	1		46.9
autoimmune thyroid disease	EFO_0006812	1	1	0	1.1	29
mean corpuscular volume	EFO_0004526	1	1	1		29

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
aspartate aminotransferase measurement	EFO_0004736	2	12.8	95.7
serum alanine aminotransferase measurement	EFO_0004735	2	15.6	94.7
Thyroid preparation use measurement	EFO_0009933	1		46.9
autoimmune thyroid disease	EFO_0006812	0	1.1	29
mean corpuscular volume	EFO_0004526	1		29

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Calcium channel
Calcium transport
Cell junction
Cell membrane
Complete proteome
Endoplasmic reticulum
Gap junction
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
aspartate aminotransferase measurement
autoimmune thyroid disease
mean corpuscular volume
serum alanine aminotransferase measurement
Thyroid preparation use measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype
respiratory system phenotype
vision/eye phenotype

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pannexin 1	VGNC:13325	466751
Macaque	pannexin 1		697204
Mouse	pannexin 1	MGI:1860055	55991
Rat	Pannexin 1	RGD:735204	315435
Dog	pannexin 1	VGNC:44254	607532

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pannexin 1
Macaque	pannexin 1
Mouse	pannexin 1
Rat	Pannexin 1
Dog	pannexin 1

Publication Statistics

PubMed Score 772.03

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PubTator Score 267.47

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