Tbio PANX1 Pannexin-1

Protein Summary

Description

Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96RD7
• O75968
• Q543A0
• Q6UW26
• Q96AM9
• Q96L77
• Q96RS5

Gene Name

• PANX1

Ensembl ID

• ENST00000227638
• ENSP00000227638
• ENSG00000110218
• ENST00000436171
• ENSP00000411461

Symbol

• MRS1
• PX1
• MRS1
• UNQ2529

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
molecular function	0.97
gene perturbation	0.86
kinase perturbation	0.81
transcription factor binding site profile	0.76

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.73   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 231   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.73   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (9)

Reactome (8)

KEGG (1)

Electric Transmission Across Gap Junctions (R-HSA-112303)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Electric Transmission Across Gap Junctions	5 targets	R-HSA-112303
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Inflammasomes	20 targets	R-HSA-622312
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neuronal System	398 targets	R-HSA-112316

Name	Explore in Pharos	Explore in Source
Electric Transmission Across Gap Junctions	5 targets	R-HSA-112303
Immune System	2246 targets	R-HSA-168256
Inflammasomes	20 targets	R-HSA-622312
Innate Immune System	1188 targets	R-HSA-168249
Neuronal System	398 targets	R-HSA-112316

Gene Ontology Terms (25)

Functions (9)

Components (8)

Processes (8)

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10

1 – 9 of 9

GO Term	Evidence	Assigned by
gap junction hemi-channel activity	Inferred from Direct Assay (IDA)	UniProtKB
signaling receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
calcium channel activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
leak channel activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
actin filament binding	Inferred from Electronic Annotation (IEA)	Ensembl
ion channel binding	Inferred from Electronic Annotation (IEA)	Ensembl
protease binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
scaffold protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (90)

Explore Interacting Targets

1 – 10 of 90

• See Interactions on String-DB

C4orf3

Tbio

Novelty: 0.00732312

p_int: 0.999930551

p_ni: 0.000061682

p_wrong: 0.000007766

Data Source: BioPlex

HTR3A

Tclin

Family: IC

Novelty: 0.00035394

p_int: 0.999928551

p_ni: 0.000059599

p_wrong: 0.00001185

Score: 0.241

Data Source: BioPlex,STRINGDB

GRPR

Tchem

Family: GPCR

Novelty: 0.00322431

p_int: 0.910188216

p_ni: 0.000909061

p_wrong: 0.088902723

Score: 0.175

Data Source: BioPlex,STRINGDB

C5AR2

Tbio

Family: GPCR

Novelty: 0.01354267

p_int: 0.818422131

p_ni: 0.000877435

p_wrong: 0.180700434

Score: 0.179

Data Source: BioPlex,STRINGDB

P2RX7

Tchem

Family: IC

Novelty: 0.00096326

Score: 0.992

Data Source: Reactome,STRINGDB

PANX2

Tbio

Family: IC

Novelty: 0.00929804

Score: 0.93

Data Source: Reactome,STRINGDB

GJA1

Tbio

Novelty: 0.00023576

Score: 0.824

Data Source: STRINGDB

P2RX1

Tchem

Family: IC

Novelty: 0.00376724

Score: 0.812

Data Source: STRINGDB

P2RX4

Tchem

Family: IC

Novelty: 0.00292374

Score: 0.792

Data Source: STRINGDB

GJB1

Tbio

Novelty: 0.00115116

Score: 0.785

Data Source: STRINGDB

Publication Statistics

PubMed Score  506.73

PubMed score by year

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PubTator Score  267.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Calcium
Calcium channel
Calcium transport
Cell junction
Cell membrane
Complete proteome
Endoplasmic reticulum
Gap junction
Glycoprotein

GWAS Trait Find Similar Targets

aspartate aminotransferase measurement
serum alanine aminotransferase measurement
Thyroid preparation use measurement

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype
respiratory system phenotype
vision/eye phenotype