Protein Summary
Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
- ENST00000227638
- ENSP00000227638
- ENSG00000110218
- ENST00000436171
- ENSP00000411461
- MRS1
- PX1
- MRS1
- UNQ2529
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.98 | ||
molecular function | 0.97 | ||
gene perturbation | 0.86 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.76 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 506.73 (req: < 5)
Gene RIFs: 75 (req: <= 3)
Antibodies: 231 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 506.73 (req: >= 5)
Gene RIFs: 75 (req: > 3)
Antibodies: 231 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (9)
Reactome (8)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Electric Transmission Across Gap Junctions | ||||
Reactome | Immune System | ||||
Reactome | Inflammasomes | ||||
Reactome | Innate Immune System | ||||
Reactome | Neuronal System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Electric Transmission Across Gap Junctions | ||||
Immune System | ||||
Inflammasomes | ||||
Innate Immune System | ||||
Neuronal System | ||||
Gene Ontology Terms (25)
Functions (9)
Components (8)
Processes (8)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (90)
1 – 10 of 90
C4orf3
Novelty: 0.00732312
p_int: 0.999930551
p_ni: 0.000061682
p_wrong: 0.000007766
Data Source: BioPlex
HTR3A
Family: IC
Novelty: 0.00035394
p_int: 0.999928551
p_ni: 0.000059599
p_wrong: 0.00001185
Score: 0.241
Data Source: BioPlex,STRINGDB
GRPR
Family: GPCR
Novelty: 0.00322431
p_int: 0.910188216
p_ni: 0.000909061
p_wrong: 0.088902723
Score: 0.175
Data Source: BioPlex,STRINGDB
C5AR2
Family: GPCR
Novelty: 0.01354267
p_int: 0.818422131
p_ni: 0.000877435
p_wrong: 0.180700434
Score: 0.179
Data Source: BioPlex,STRINGDB
P2RX7
Family: IC
Novelty: 0.00096326
Score: 0.992
Data Source: Reactome,STRINGDB
PANX2
Family: IC
Novelty: 0.00929804
Score: 0.93
Data Source: Reactome,STRINGDB
GJA1
Novelty: 0.00023576
Score: 0.824
Data Source: STRINGDB
P2RX1
Family: IC
Novelty: 0.00376724
Score: 0.812
Data Source: STRINGDB
P2RX4
Family: IC
Novelty: 0.00292374
Score: 0.792
Data Source: STRINGDB
GJB1
Novelty: 0.00115116
Score: 0.785
Data Source: STRINGDB
Publication Statistics
PubMed Score 506.73
PubMed score by year
PubTator Score 267.47
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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