Tbio PANX2 Pannexin-2

Protein Summary

Description

Structural component of the gap junctions and the hemichannels. The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• Q96RD6
• B7Z684
• Q96RD5
• Q9UGX8

Gene Name

• PANX2

Ensembl ID

• ENST00000159647
• ENSP00000159647
• ENSG00000073150
• ENST00000395842
• ENSP00000379183

Symbol

• PX2
• hPANX2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.77
histone modification site profile	0.54
cellular component	0.51
cell line	0.5
virus perturbation	0.5

Protein Classes

DTO Classes

Protein / Ion Channel / Gap Junction-forming Innexin (Innexin) Family / Pannexin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.26   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.26   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0