MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Protein Summary
May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000330909
- ENSP00000331157
- ENSG00000151276
- ENST00000402939
- ENSP00000385450
- ENST00000483466
- ENSP00000420323
- ENST00000497477
- ENSP00000424369
- ENST00000634409
- ENSP00000489444
- ENSG00000282956
- ENST00000634774
- ENSP00000489393
- ENST00000635378
- ENSP00000489391
- ENST00000635471
- ENSP00000489322
- AIP3
- BAIAP1
- BAP1
- TNRC19
- AIP3
- BAP1
- WWP3
- AIP-3
- BAP-1
- BAIAP1
- MAGI-1
- Magi1d
- TNRC19
- MAGI-1b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
viral protein | 1 | ||
virus | 1 | ||
trait | 0.97 | ||
protein domain | 0.92 | ||
disease perturbation | 0.9 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.33 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.33 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (34)
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1 – 5 of 34
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 2 | 2 | 85.8 | ||||||
self reported educational attainment | 1 | 2 | 2 | 85.8 | ||||||
adolescent idiopathic scoliosis | 1 | 1 | 0 | 1.2 | 74.9 | |||||
adolescent idiopathic scoliosis | 1 | 1 | 0 | 1.2 | 74.9 | |||||
neuroticism measurement | 2 | 2 | 1 | 5.7 | 70.4 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 2 | 85.8 | |||||
self reported educational attainment | 2 | 85.8 | |||||
adolescent idiopathic scoliosis | 0 | 1.2 | 74.9 | ||||
adolescent idiopathic scoliosis | 0 | 1.2 | 74.9 | ||||
neuroticism measurement | 1 | 5.7 | 70.4 | ||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | membrane associated guanylate kinase, WW and PDZ domain containing 1 | VGNC:7074 | 465215 | |||||
Macaque | membrane associated guanylate kinase, WW and PDZ domain containing 1 | 698092 | ||||||
Mouse | MGI:1203522 | 14924 | ||||||
Rat | RGD:1586025 | 500261 | ||||||
Horse | membrane associated guanylate kinase, WW and PDZ domain containing 1 | VGNC:19895 | 100049816 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | membrane associated guanylate kinase, WW and PDZ domain containing 1 | |||||
Macaque | membrane associated guanylate kinase, WW and PDZ domain containing 1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | membrane associated guanylate kinase, WW and PDZ domain containing 1 | |||||
Protein Structure (12 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (10)
KEGG (4)
PathwayCommons (1)
WikiPathways (5)
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | PI3K-Akt signaling pathway | ||||
KEGG | Tight junction | ||||
KEGG | Rap1 signaling pathway | ||||
KEGG | Human papillomavirus infection | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
PI3K-Akt signaling pathway | ||||
Tight junction | ||||
Rap1 signaling pathway | ||||
Human papillomavirus infection | ||||
Gene Ontology Terms (15)
Functions (4)
Components (8)
Processes (3)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (67)
1 – 10 of 67
PTPN14
Family: Enzyme
Novelty: 0.01333024
p_int: 0.999999993
p_ni: 5e-9
p_wrong: 2e-9
Score: 0.399
Data Source: BioPlex,STRINGDB
LDLRAD4
Novelty: 0.04881486
p_int: 0.99999885
p_ni: 0.000001075
p_wrong: 7.4e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
CYYR1
Novelty: 0.19732526
p_int: 0.999926169
p_ni: 0.000015548
p_wrong: 0.000058283
Score: 0.5
Data Source: BioPlex,STRINGDB
RAPGEF2
Novelty: 0.03353183
Score: 0.938
Data Source: STRINGDB
CTNNB1
Novelty: 0.0000744
Score: 0.931
Data Source: STRINGDB
PTEN
Family: Enzyme
Novelty: 0.00013818
Score: 0.857
Data Source: STRINGDB
IGSF5
Novelty: 0.11695258
Score: 0.844
Data Source: STRINGDB
SYNPO
Novelty: 0.00461054
Score: 0.841
Data Source: STRINGDB
UBE3A
Family: Enzyme
Novelty: 0.00149368
Score: 0.84
Data Source: STRINGDB
MAGI3
Family: Enzyme
Novelty: 0.03968945
Score: 0.824
Data Source: STRINGDB
Publication Statistics
PubMed Score 15.33
PubMed score by year
PubTator Score 42.85
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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