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Tbio
MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Protein Summary
Description
May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330909
  • ENSP00000331157
  • ENSG00000151276
  • ENST00000402939
  • ENSP00000385450
  • ENST00000483466
  • ENSP00000420323
  • ENST00000497477
  • ENSP00000424369
  • ENST00000634409
  • ENSP00000489444
  • ENSG00000282956
  • ENST00000634774
  • ENSP00000489393
  • ENST00000635378
  • ENSP00000489391
  • ENST00000635471
  • ENSP00000489322

Symbol
  • AIP3
  • BAIAP1
  • BAP1
  • TNRC19
  • AIP3
  • BAP1
  • WWP3
  • AIP-3
  • BAP-1
  • BAIAP1
  • MAGI-1
  • Magi1d
  • TNRC19
  • MAGI-1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
1
trait
0.97
protein domain
0.92
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (34)
Items per page:
1 – 5 of 34
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
85.8
self reported educational attainment
1
2
2
85.8
adolescent idiopathic scoliosis
1
1
0
1.2
74.9
adolescent idiopathic scoliosis
1
1
0
1.2
74.9
neuroticism measurement
2
2
1
5.7
70.4
Items per page:
1 – 5 of 34
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
85.8
self reported educational attainment
2
85.8
adolescent idiopathic scoliosis
0
1.2
74.9
adolescent idiopathic scoliosis
0
1.2
74.9
neuroticism measurement
1
5.7
70.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane associated guanylate kinase, WW and PDZ domain containing 1
VGNC:7074
465215
Macaque
membrane associated guanylate kinase, WW and PDZ domain containing 1
698092
Mouse
MGI:1203522
14924
Rat
RGD:1586025
500261
Horse
membrane associated guanylate kinase, WW and PDZ domain containing 1
VGNC:19895
100049816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane associated guanylate kinase, WW and PDZ domain containing 1
Macaque
membrane associated guanylate kinase, WW and PDZ domain containing 1
Mouse
Rat
Horse
membrane associated guanylate kinase, WW and PDZ domain containing 1
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96QZ7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PI3K-Akt signaling pathway
KEGG
Tight junction
KEGG
Rap1 signaling pathway
KEGG
Human papillomavirus infection
Name
Explore in Pharos
Explore in Source
PI3K-Akt signaling pathway
Tight junction
Rap1 signaling pathway
Human papillomavirus infection
Protein-Protein Interactions (67)
1 – 10 of 67
PTPN14
Tbio
Family: Enzyme
Novelty: 0.01333024
p_int: 0.999999993
p_ni: 5e-9
p_wrong: 2e-9
Score: 0.399
Data Source: BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty: 0.04881486
p_int: 0.99999885
p_ni: 0.000001075
p_wrong: 7.4e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
CYYR1
Tbio
Novelty: 0.19732526
p_int: 0.999926169
p_ni: 0.000015548
p_wrong: 0.000058283
Score: 0.5
Data Source: BioPlex,STRINGDB
RAPGEF2
Tbio
Novelty: 0.03353183
Score: 0.938
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.931
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00013818
Score: 0.857
Data Source: STRINGDB
IGSF5
Tbio
Novelty: 0.11695258
Score: 0.844
Data Source: STRINGDB
SYNPO
Tbio
Novelty: 0.00461054
Score: 0.841
Data Source: STRINGDB
UBE3A
Tbio
Family: Enzyme
Novelty: 0.00149368
Score: 0.84
Data Source: STRINGDB
MAGI3
Tbio
Family: Enzyme
Novelty: 0.03968945
Score: 0.824
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.33

PubMed score by year
PubTator Score  42.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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