Tbio MAGI1 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Protein Summary

Description

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96QZ7
• A8K188
• O00309
• O43863
• O75085
• Q96QZ8
• Q96QZ9

Gene Name

• MAGI1

Ensembl ID

• ENST00000330909
• ENSP00000331157
• ENSG00000151276
• ENST00000402939
• ENSP00000385450
• ENST00000483466
• ENSP00000420323
• ENST00000497477
• ENSP00000424369
• ENST00000634409
• ENSP00000489444
• ENSG00000282956
• ENST00000634774
• ENSP00000489393
• ENST00000635378
• ENSP00000489391
• ENST00000635471
• ENSP00000489322

Symbol

• AIP3
• BAIAP1
• BAP1
• TNRC19
• AIP3
• BAP1
• WWP3
• AIP-3
• BAP-1
• BAIAP1
• MAGI-1
• Magi1d
• TNRC19
• MAGI-1b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
viral protein	1
virus	1
trait	0.97
protein domain	0.92
disease perturbation	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.33   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (67)

Explore Interacting Targets

1 – 10 of 67

• See Interactions on String-DB

PTPN14

Tbio

Family:  Enzyme

Novelty:  0.01333024

p_int:  0.999999993

p_ni:  5e-9

p_wrong:  2e-9

Score:  0.399

Data Source:  BioPlex,STRINGDB

LDLRAD4

Tbio

Novelty:  0.04881486

p_int:  0.99999885

p_ni:  0.000001075

p_wrong:  7.4e-8

Score:  0.173

Data Source:  BioPlex,STRINGDB

CYYR1

Tbio

Novelty:  0.19732526

p_int:  0.999926169

p_ni:  0.000015548

p_wrong:  0.000058283

Score:  0.5

Data Source:  BioPlex,STRINGDB

RAPGEF2

Tbio

Novelty:  0.03353183

Score:  0.938

Data Source:  STRINGDB

CTNNB1

Tchem

Novelty:  0.0000744

Score:  0.931

Data Source:  STRINGDB

PTEN

Tchem

Family:  Enzyme

Novelty:  0.00013818

Score:  0.857

Data Source:  STRINGDB

IGSF5

Tbio

Novelty:  0.11695258

Score:  0.844

Data Source:  STRINGDB

SYNPO

Tbio

Novelty:  0.00461054

Score:  0.841

Data Source:  STRINGDB

UBE3A

Tbio

Family:  Enzyme

Novelty:  0.00149368

Score:  0.84

Data Source:  STRINGDB

MAGI3

Tbio

Family:  Enzyme

Novelty:  0.03968945

Score:  0.824

Data Source:  STRINGDB

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Downstream (3)

1 – 3 of 3

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  3

1: PI3K-Akt signaling pathway

2: Rap1 signaling pathway

3: Human papillomavirus infection

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  3

1: PI3K-Akt signaling pathway

2: Rap1 signaling pathway

3: Human papillomavirus infection

BRAF

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  1

1: Rap1 signaling pathway

Pathways (10)

KEGG (4)

PathwayCommons (1)

WikiPathways (5)

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	PI3K-Akt signaling pathway	351 targets	path:hsa04151
KEGG	Tight junction	169 targets	path:hsa04530
KEGG	Rap1 signaling pathway	213 targets	path:hsa04015
KEGG	Human papillomavirus infection	399 targets	path:hsa05165

Name	Explore in Pharos	Explore in Source
PI3K-Akt signaling pathway	351 targets	path:hsa04151
Tight junction	169 targets	path:hsa04530
Rap1 signaling pathway	213 targets	path:hsa04015
Human papillomavirus infection	399 targets	path:hsa05165

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (4)

Components (8)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
alpha-actinin binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein C-terminus binding	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein-containing complex scaffold activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (32)

Items per page:

5

1 – 5 of 32

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
viral load	EFO_0010125	ENSG00000282956	1	1	1		66
viral load	EFO_0010125	ENSG00000151276	1	1	1		66
self reported educational attainment	EFO_0004784	ENSG00000151276	1	2	2		65.7
self reported educational attainment	EFO_0004784	ENSG00000282956	1	2	2		65.7
adolescent idiopathic scoliosis	EFO_0005423	ENSG00000282956	1	1	0	1.2	54.4

Items per page:

5

1 – 5 of 32

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
viral load	EFO_0010125	1		66
viral load	EFO_0010125	1		66
self reported educational attainment	EFO_0004784	2		65.7
self reported educational attainment	EFO_0004784	2		65.7
adolescent idiopathic scoliosis	EFO_0005423	0	1.2	54.4

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ATP-binding
Cell junction
Cell membrane
Complete proteome
Membrane
Nucleotide-binding
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
adolescent idiopathic scoliosis
comparative body size at age 10, self-reported
complicated disease course
Crohn's disease
Erythema nodosum
ileocolitis
mathematical ability
mild disease course
neuroticism measurement
ocular sarcoidosis

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	membrane associated guanylate kinase, WW and PDZ domain containing 1	VGNC:7074	465215
Macaque	membrane associated guanylate kinase, WW and PDZ domain containing 1		698092
Mouse	membrane associated guanylate kinase, WW and PDZ domain containing 1	MGI:1203522	14924
Rat	membrane associated guanylate kinase, WW and PDZ domain containing 1	RGD:1586025	500261
Horse	membrane associated guanylate kinase, WW and PDZ domain containing 1	VGNC:19895	100049816

Species	Name	OMA	EggNOG	Inparanoid
Chimp	membrane associated guanylate kinase, WW and PDZ domain containing 1
Macaque	membrane associated guanylate kinase, WW and PDZ domain containing 1
Mouse	membrane associated guanylate kinase, WW and PDZ domain containing 1
Rat	membrane associated guanylate kinase, WW and PDZ domain containing 1
Horse	membrane associated guanylate kinase, WW and PDZ domain containing 1

Publication Statistics

PubMed Score 15.33

PubMed score by year

Reset Zoom

PubTator Score 42.85

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (51)

GeneRif Annotations (25)

Items per page:

10

0 of 0

PMID	Year	Title