Tbio MAGI1 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Protein Summary

Description

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96QZ7
• A8K188
• O00309
• O43863
• O75085
• Q96QZ8
• Q96QZ9

Gene Name

• MAGI1

Ensembl ID

• ENST00000330909
• ENSP00000331157
• ENSG00000151276
• ENST00000402939
• ENSP00000385450
• ENST00000483466
• ENSP00000420323
• ENST00000497477
• ENSP00000424369
• ENST00000634409
• ENSP00000489444
• ENSG00000282956
• ENST00000634774
• ENSP00000489393
• ENST00000635378
• ENSP00000489391
• ENST00000635471
• ENSP00000489322

Symbol

• AIP3
• BAIAP1
• BAP1
• TNRC19
• AIP3
• BAP1
• WWP3
• AIP-3
• BAP-1
• BAIAP1
• MAGI-1
• Magi1d
• TNRC19
• MAGI-1b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
viral protein	1
virus	1
trait	0.97
protein domain	0.92
disease perturbation	0.9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.73   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.73   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (12)

1 – 5 of 12

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (10)

KEGG (4)

PathwayCommons (1)

WikiPathways (5)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	PI3K-Akt signaling pathway	351 targets	path:hsa04151
KEGG	Tight junction	169 targets	path:hsa04530
KEGG	Rap1 signaling pathway	213 targets	path:hsa04015
KEGG	Human papillomavirus infection	399 targets	path:hsa05165

Name	Explore in Pharos	Explore in Source
PI3K-Akt signaling pathway	351 targets	path:hsa04151
Tight junction	169 targets	path:hsa04530
Rap1 signaling pathway	213 targets	path:hsa04015
Human papillomavirus infection	399 targets	path:hsa05165

Gene Ontology Terms (15)

Functions (4)

Components (8)

Processes (3)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
alpha-actinin binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein C-terminus binding	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein-containing complex scaffold activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (67)

Explore Interacting Targets

1 – 10 of 67

• See Interactions on String-DB

PTPN14

Tbio

Family: Enzyme

Novelty: 0.01972265

p_int: 0.999999993

p_ni: 5e-9

p_wrong: 2e-9

Score: 0.399

Data Source: BioPlex,STRINGDB

LDLRAD4

Tbio

Novelty: 0.02672907

p_int: 0.99999885

p_ni: 0.000001075

p_wrong: 7.4e-8

Score: 0.173

Data Source: BioPlex,STRINGDB

CYYR1

Tdark

Novelty: 0.22554189

p_int: 0.999926169

p_ni: 0.000015548

p_wrong: 0.000058283

Score: 0.5

Data Source: BioPlex,STRINGDB

RAPGEF2

Tbio

Novelty: 0.0389972

Score: 0.938

Data Source: STRINGDB

CTNNB1

Tchem

Novelty: 0.00008951

Score: 0.931

Data Source: STRINGDB

PTEN

Tchem

Family: Enzyme

Novelty: 0.00017995

Score: 0.857

Data Source: STRINGDB

IGSF5

Tbio

Novelty: 0.16900008

Score: 0.844

Data Source: STRINGDB

SYNPO

Tbio

Novelty: 0.00583594

Score: 0.841

Data Source: STRINGDB

UBE3A

Tbio

Family: Enzyme

Novelty: 0.00207153

Score: 0.84

Data Source: STRINGDB

MAGI3

Tbio

Family: Enzyme

Novelty: 0.06036555

Score: 0.824

Data Source: STRINGDB

Publication Statistics

PubMed Score  11.73

PubMed score by year

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PubTator Score  42.85

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
ATP-binding
Cell junction
Cell membrane
Complete proteome
Membrane
Nucleotide-binding
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

adolescent idiopathic scoliosis
complicated disease course
Crohn's disease
depressive symptom measurement
Erythema nodosum
HIV-1 infection
ileocolitis
mathematical ability
mild disease course
mood disorder