You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Protein Summary
Description
May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330909
  • ENSP00000331157
  • ENSG00000151276
  • ENST00000402939
  • ENSP00000385450
  • ENST00000483466
  • ENSP00000420323
  • ENST00000497477
  • ENSP00000424369
  • ENST00000634409
  • ENSP00000489444
  • ENSG00000282956
  • ENST00000634774
  • ENSP00000489393
  • ENST00000635378
  • ENSP00000489391
  • ENST00000635471
  • ENSP00000489322

Symbol
  • AIP3
  • BAIAP1
  • BAP1
  • TNRC19
  • AIP3
  • BAP1
  • WWP3
  • AIP-3
  • BAP-1
  • BAIAP1
  • MAGI-1
  • Magi1d
  • TNRC19
  • MAGI-1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
1
trait
0.97
protein domain
0.92
disease perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.73   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.73   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PI3K-Akt signaling pathway
KEGG
Tight junction
KEGG
Rap1 signaling pathway
KEGG
Human papillomavirus infection
Name
Explore in Pharos
Explore in Source
PI3K-Akt signaling pathway
Tight junction
Rap1 signaling pathway
Human papillomavirus infection
Protein-Protein Interactions (67)
1 – 10 of 67
PTPN14
Tbio
Family: Enzyme
Novelty: 0.01972265
p_int: 0.999999993
p_ni: 5e-9
p_wrong: 2e-9
Score: 0.399
Data Source: BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty: 0.02672907
p_int: 0.99999885
p_ni: 0.000001075
p_wrong: 7.4e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
CYYR1
Tdark
Novelty: 0.22554189
p_int: 0.999926169
p_ni: 0.000015548
p_wrong: 0.000058283
Score: 0.5
Data Source: BioPlex,STRINGDB
RAPGEF2
Tbio
Novelty: 0.0389972
Score: 0.938
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.00008951
Score: 0.931
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00017995
Score: 0.857
Data Source: STRINGDB
IGSF5
Tbio
Novelty: 0.16900008
Score: 0.844
Data Source: STRINGDB
SYNPO
Tbio
Novelty: 0.00583594
Score: 0.841
Data Source: STRINGDB
UBE3A
Tbio
Family: Enzyme
Novelty: 0.00207153
Score: 0.84
Data Source: STRINGDB
MAGI3
Tbio
Family: Enzyme
Novelty: 0.06036555
Score: 0.824
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.73

PubMed score by year
PubTator Score  42.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: