Tbio PANX3 Pannexin-3

Protein Summary

Description

Structural component of the gap junctions and the hemichannels. The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96QZ0

Gene Name

• PANX3

Ensembl ID

• ENST00000284288
• ENSP00000284288
• ENSG00000154143

Symbol

• PX3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.61
cell line	0.57
cell type or tissue	0.53
gene perturbation	0.53
cellular component	0.44

Protein Classes

DTO Classes

Protein / Ion Channel / Gap Junction-forming Innexin (Innexin) Family / Pannexin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.38   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 85   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.38   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0