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Tbio
HHIP
Hedgehog-interacting protein

Protein Summary
Description
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296575
  • ENSP00000296575
  • ENSG00000164161
  • ENST00000434550
  • ENSP00000408587

Symbol
  • HIP
  • HIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
kinase perturbation
0.88
protein domain
0.85
PubMedID
0.74
disease
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.87   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.87   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
4
7
8.3
98.4
BMI-adjusted waist-hip ratio
1
1
1
87.9
birth weight
3
2
3
84.7
body mass index
3
1
4
78.5
2
2
0
1.1
78.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
8.3
98.4
BMI-adjusted waist-hip ratio
1
87.9
birth weight
3
84.7
body mass index
4
78.5
0
1.1
78.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hedgehog interacting protein
VGNC:612
461521
Macaque
hedgehog interacting protein
701205
Mouse
MGI:1341847
15245
Rat
RGD:1564108
291936
Dog
hedgehog interacting protein
VGNC:41681
100855424
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hedgehog interacting protein
Macaque
hedgehog interacting protein
Mouse
Rat
Dog
hedgehog interacting protein
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96QV1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
GLI proteins bind promoters of Hh responsive genes to promote transcription (R-HSA-5635851)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Reactome
Hedgehog 'on' state
Reactome
Ligand-receptor interactions
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
GLI proteins bind promoters of Hh responsive genes to promote transcription
Hedgehog 'on' state
Ligand-receptor interactions
Signal Transduction
Signaling by Hedgehog
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (65)
1 – 10 of 65
SHH
Tchem
Novelty: 0.00028347
Score: 0.998
Data Source: Reactome,STRINGDB
DHH
Tbio
Novelty: 0.00329784
Score: 0.995
Data Source: STRINGDB
IHH
Tbio
Novelty: 0.00174847
Score: 0.98
Data Source: STRINGDB
GLI1
Tchem
Family: TF
Novelty: 0.00077281
Score: 0.97
Data Source: STRINGDB
GLI2
Tchem
Family: TF
Novelty: 0.00229126
Score: 0.94
Data Source: STRINGDB
GLI3
Tbio
Family: TF
Novelty: 0.00051217
Score: 0.933
Data Source: STRINGDB
PTCH1
Tbio
Novelty: 0.00077635
Score: 0.872
Data Source: STRINGDB
FAM13A
Tbio
Novelty: 0.02851485
Score: 0.789
Data Source: STRINGDB
PTCH2
Tbio
Novelty: 0.00927849
Score: 0.706
Data Source: STRINGDB
CHRNA3
Tclin
Family: IC
Novelty: 0.00659767
Score: 0.699
Data Source: STRINGDB
Publication Statistics
PubMed Score  96.87

PubMed score by year
PubTator Score  51.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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