Protein Summary
Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function. This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008]
- ENST00000320301
- ENSP00000322604
- ENSG00000150275
- ENST00000373955
- ENSP00000363066
- ENST00000395445
- ENSP00000378832
- ENST00000616114
- ENSP00000483745
- USH1F
- USH1F
- CDHR15
- DFNB23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
virus perturbation | 0.99 | ||
disease | 0.75 | ||
phenotype | 0.74 | ||
cellular component | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.26 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.26 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (87)
Nearest Tclin Targets
Pathways (2)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (1)
Components (6)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 2 | 2 | 65.3 | |||||
serum metabolite measurement | 1 | 1 | 4 | 44.2 | |||||
extraversion | 1 | 1 | 1 | 38.8 | |||||
1 | 1 | 0 | 1.3 | 37.6 | |||||
risk-taking behaviour | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 65.3 | |||||
serum metabolite measurement | 4 | 44.2 | |||||
extraversion | 1 | 38.8 | |||||
0 | 1.3 | 37.6 | |||||
risk-taking behaviour | 1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | protocadherin related 15 | 702413 | ||||||
Mouse | MGI:1891428 | 11994 | ||||||
Rat | RGD:1590969 | 690865 | ||||||
Dog | protocadherin related 15 | VGNC:52955 | 609280 | |||||
Cow | protocadherin related 15 | VGNC:32617 | 100140108 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | protocadherin related 15 | |||||
Mouse | ||||||
Rat | ||||||
Dog | protocadherin related 15 | |||||
Cow | protocadherin related 15 | |||||
Publication Statistics
PubMed Score 112.26
PubMed score by year
PubTator Score 72.07
PubTator score by year
Related Publications
Text Mined References (111)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
|---|