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Tbio
PCDH15
Protocadherin-15

Protein Summary
Description
Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function. This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320301
  • ENSP00000322604
  • ENSG00000150275
  • ENST00000373955
  • ENSP00000363066
  • ENST00000395445
  • ENSP00000378832
  • ENST00000616114
  • ENSP00000483745

Symbol
  • USH1F
  • USH1F
  • CDHR15
  • DFNB23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
virus perturbation
0.99
disease
0.75
phenotype
0.74
cellular component
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.26   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.26   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
USH1C
Tbio
Novelty:  0.01066917
Score:  0.964
Data Source:  STRINGDB
MYO7A
Tbio
Novelty:  0.00314435
Score:  0.937
Data Source:  STRINGDB
LHFPL5
Tbio
Novelty:  0.03689538
Score:  0.914
Data Source:  STRINGDB
USH1G
Tbio
Novelty:  0.02912203
Score:  0.902
Data Source:  STRINGDB
CDH23
Tbio
Novelty:  0.00588227
Score:  0.882
Data Source:  STRINGDB
WHRN
Tbio
Novelty:  0.01886351
Score:  0.858
Data Source:  STRINGDB
TMIE
Tbio
Novelty:  0.02939225
Score:  0.858
Data Source:  STRINGDB
USH2A
Tbio
Novelty:  0.00223387
Score:  0.838
Data Source:  STRINGDB
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
Score:  0.824
Data Source:  STRINGDB
MYO15A
Tbio
Novelty:  0.0148787
Score:  0.822
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
65.3
serum metabolite measurement
1
1
4
44.2
extraversion
1
1
1
38.8
1
1
0
1.3
37.6
risk-taking behaviour
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
65.3
serum metabolite measurement
4
44.2
extraversion
1
38.8
0
1.3
37.6
risk-taking behaviour
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protocadherin related 15
702413
Mouse
MGI:1891428
11994
Rat
RGD:1590969
690865
Dog
protocadherin related 15
VGNC:52955
609280
Cow
protocadherin related 15
VGNC:32617
100140108
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protocadherin related 15
Mouse
Rat
Dog
protocadherin related 15
Cow
protocadherin related 15
Publication Statistics
PubMed Score 112.26
PubMed score by year
PubTator Score 72.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title