PCDH15
Protocadherin-15
Protein Summary
Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function. This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008]
- ENST00000320301
- ENSP00000322604
- ENSG00000150275
- ENST00000373955
- ENSP00000363066
- ENST00000395445
- ENSP00000378832
- ENST00000616114
- ENSP00000483745
- USH1F
- USH1F
- CDHR15
- DFNB23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
virus perturbation | 0.99 | ||
disease | 0.75 | ||
phenotype | 0.74 | ||
cellular component | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 129.25 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 129.25 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0