Protein Summary
Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function. This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008]
- ENST00000320301
- ENSP00000322604
- ENSG00000150275
- ENST00000373955
- ENSP00000363066
- ENST00000395445
- ENSP00000378832
- ENST00000616114
- ENSP00000483745
- USH1F
- USH1F
- CDHR15
- DFNB23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
virus perturbation | 0.99 | ||
disease | 0.75 | ||
phenotype | 0.74 | ||
cellular component | 0.73 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.26 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.26 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 2 | 2 | 65.3 | |||||
serum metabolite measurement | 1 | 1 | 4 | 44.2 | |||||
extraversion | 1 | 1 | 1 | 38.8 | |||||
1 | 1 | 0 | 1.3 | 37.6 | |||||
risk-taking behaviour | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 65.3 | |||||
serum metabolite measurement | 4 | 44.2 | |||||
extraversion | 1 | 38.8 | |||||
0 | 1.3 | 37.6 | |||||
risk-taking behaviour | 1 | 30.2 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | protocadherin related 15 | 702413 | ||||||
Mouse | MGI:1891428 | 11994 | ||||||
Rat | RGD:1590969 | 690865 | ||||||
Dog | protocadherin related 15 | VGNC:52955 | 609280 | |||||
Cow | protocadherin related 15 | VGNC:32617 | 100140108 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | protocadherin related 15 | |||||
Mouse | ||||||
Rat | ||||||
Dog | protocadherin related 15 | |||||
Cow | protocadherin related 15 | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (2)
PathwayCommons (2)
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Gene Ontology Terms (14)
Functions (1)
Components (6)
Processes (7)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (87)
1 – 10 of 87
USH1C
Novelty: 0.01066917
Score: 0.964
Data Source: STRINGDB
MYO7A
Novelty: 0.00314435
Score: 0.937
Data Source: STRINGDB
LHFPL5
Novelty: 0.03689538
Score: 0.914
Data Source: STRINGDB
USH1G
Novelty: 0.02912203
Score: 0.902
Data Source: STRINGDB
CDH23
Novelty: 0.00588227
Score: 0.882
Data Source: STRINGDB
WHRN
Novelty: 0.01886351
Score: 0.858
Data Source: STRINGDB
TMIE
Novelty: 0.02939225
Score: 0.858
Data Source: STRINGDB
USH2A
Novelty: 0.00223387
Score: 0.838
Data Source: STRINGDB
ADGRV1
Family: GPCR
Novelty: 0.01398129
Score: 0.824
Data Source: STRINGDB
MYO15A
Novelty: 0.0148787
Score: 0.822
Data Source: STRINGDB
Publication Statistics
PubMed Score 112.26
PubMed score by year
PubTator Score 72.07
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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GWAS Trait
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