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Tbio
PHF12
PHD finger protein 12

Protein Summary
Description
Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268756
  • ENSP00000268756
  • ENSG00000109118
  • ENST00000332830
  • ENSP00000329933
  • ENST00000577226
  • ENSP00000465161

Symbol
  • KIAA1523
  • PF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
protein domain
0.92
transcription factor
0.81
cellular component
0.79
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.24   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.24   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
p_int:  0.999999989
p_ni:  9e-9
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999974
p_ni:  2.5e-8
p_wrong:  1e-9
Score:  0.976
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.9999999
p_ni:  9.9e-8
Score:  0.987
Data Source:  BioPlex,STRINGDB
MORF4L2
Tbio
Novelty:  0.09897629
p_int:  0.999988131
p_ni:  0.000011868
Score:  0.974
Data Source:  BioPlex,STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.998
Data Source:  STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.986
Data Source:  STRINGDB
SIN3B
Tbio
Novelty:  0.04097105
Score:  0.985
Data Source:  STRINGDB
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
Score:  0.972
Data Source:  STRINGDB
HDAC8
Tclin
Family:  Epigenetic
Novelty:  0.0023827
Score:  0.958
Data Source:  STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
4
98.8
mean corpuscular hemoglobin concentration
4
4
4
98.2
reticulocyte count
4
3
4
94
reticulocyte measurement
2
2
2
89.1
HbA1c measurement
3
3
4
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
98.8
mean corpuscular hemoglobin concentration
4
98.2
reticulocyte count
4
94
reticulocyte measurement
2
89.1
HbA1c measurement
4
86.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 12
VGNC:9522
454538
Macaque
PHD finger protein 12
710851
Mouse
MGI:1924057
268448
Rat
RGD:1305731
303274
Dog
PHD finger protein 12
VGNC:44482
491174
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 12
Macaque
PHD finger protein 12
Mouse
Rat
Dog
PHD finger protein 12
Publication Statistics
PubMed Score 433.24
PubMed score by year
PubTator Score 167.40
PubTator score by year
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Related Publications
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PMID
Year
Title