Tchem TRPM7 Transient receptor potential cation channel subfamily M member 7

Protein Summary

Description

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• Q96QT4
• Q6ZMF5
• Q86VJ4
• Q8NBW2
• Q9BXB2
• Q9NXQ2

Gene Name

• TRPM7

Ensembl ID

• ENST00000313478
• ENSP00000320239
• ENSG00000092439
• ENST00000646667
• ENSP00000495860

Symbol

• CHAK1
• LTRPC7
• CHAK
• CHAK1
• ALSPDC
• LTRPC7
• LTrpC-7
• TRP-PLIK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
cell type or tissue	0.92
histone modification site profile	0.84
transcription factor binding site profile	0.83
cell line	0.72

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Transient Receptor Potential Cation Channel Subfamily M Member 7

Protein / Receptor / Transient Receptor Potential Cation Channel Subfamily M Member 7

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Ltrpc Subfamily / Trpm7 Sub-subfamily / Transient Receptor Potential Cation Channel Subfamily M Member 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 540.23   (req: < 5)

Gene RIFs: 171   (req: <= 3)

Antibodies: 421   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 540.23   (req: >= 5)

Gene RIFs: 171   (req: > 3)

Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2