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Tchem
TRPM7
Transient receptor potential cation channel subfamily M member 7

Protein Summary
Description
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313478
  • ENSP00000320239
  • ENSG00000092439
  • ENST00000646667
  • ENSP00000495860

Symbol
  • CHAK1
  • LTRPC7
  • CHAK
  • CHAK1
  • ALSPDC
  • LTRPC7
  • LTrpC-7
  • TRP-PLIK
Illumination Graph
Knowledge Table


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 540.23   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 421   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 540.23   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2