Tchem TRPM7 Transient receptor potential cation channel subfamily M member 7

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Transient Receptor Potential Cation Channel Subfamily M Member 7

Protein / Receptor / Transient Receptor Potential Cation Channel Subfamily M Member 7

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Ltrpc Subfamily / Trpm7 Sub-subfamily / Transient Receptor Potential Cation Channel Subfamily M Member 7

Protein Summary

Description

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• Q96QT4
• Q6ZMF5
• Q86VJ4
• Q8NBW2
• Q9BXB2
• Q9NXQ2

Gene Name

• TRPM7

Ensembl ID

• ENST00000313478
• ENSP00000320239
• ENSG00000092439
• ENST00000646667
• ENSP00000495860

Symbol

• CHAK1
• LTRPC7
• CHAK
• CHAK1
• ALSPDC
• LTRPC7
• LTrpC-7
• TRP-PLIK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
cell type or tissue	0.92
histone modification site profile	0.84
transcription factor binding site profile	0.83
cell line	0.72

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.75   (req: < 5)

Gene RIFs: 119   (req: <= 3)

Antibodies: 421   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.75   (req: >= 5)

Gene RIFs: 119   (req: > 3)

Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

nafamostat

TRPM7Tchem IC

IC50 : 3.21

fingolimod

TRPM7Tchem IC

IC50 : 6.14

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

CHEMBL23194

TRPM7Tchem IC

Ki : 5.63999987

Mg²⁺

TRPM7Tchem IC

IC50 : 2.49000001

CHEMBL169233

TRPM7Tchem IC

IC50 : 3.75

CHEMBL510780

TRPM7Tchem IC

IC50 : 5.8

sphingosine

TRPM7Tchem IC

IC50 : 6.23

carvacrol

TRPM7Tchem IC

IC50 : 3.51999998

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	1	1	1		65.4
household income	EFO_0009695	1	1	1		11.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	1		65.4
household income	EFO_0009695	1		11.6

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transient receptor potential cation channel subfamily M member 7	VGNC:7522	453429
Macaque	transient receptor potential cation channel subfamily M member 7		716755
Mouse	transient receptor potential cation channel, subfamily M, member 7	MGI:1929996	58800
Rat	transient receptor potential cation channel, subfamily M, member 7	RGD:620053	679906
Dog	transient receptor potential cation channel subfamily M member 7	VGNC:47878	478300

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transient receptor potential cation channel subfamily M member 7
Macaque	transient receptor potential cation channel subfamily M member 7
Mouse	transient receptor potential cation channel, subfamily M, member 7
Rat	transient receptor potential cation channel, subfamily M, member 7
Dog	transient receptor potential cation channel subfamily M member 7

Pathways (8)

Reactome (4)

KEGG (4)

Ion channel transport (R-HSA-983712)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Stimuli-sensing channels	102 targets	R-HSA-2672351
Reactome	TRP channels	25 targets	R-HSA-3295583
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Ion channel transport	179 targets	R-HSA-983712
Stimuli-sensing channels	102 targets	R-HSA-2672351
TRP channels	25 targets	R-HSA-3295583
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (16)

Functions (6)

Components (3)

Processes (7)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
calcium channel activity	Traceable Author Statement (TAS)	Reactome
actin binding	Inferred from Electronic Annotation (IEA)	Ensembl
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
myosin binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein serine/threonine kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (89)

Explore Interacting Targets

1 – 10 of 89

• See Interactions on String-DB

ARL15

Tbio

Family: Enzyme

Novelty: 0.09327102

p_int: 0.999999312

p_ni: 3.55e-7

p_wrong: 3.34e-7

Score: 0.264

Data Source: BioPlex,STRINGDB

TEX28

Tdark

Novelty: 0.10581423

p_int: 0.999991451

p_ni: 0.000008548

p_wrong: 1e-9

Score: 0.161

Data Source: BioPlex,STRINGDB

SNAP29

Tbio

Novelty: 0.02009206

p_int: 0.999957052

p_ni: 0.000042932

p_wrong: 1.6e-8

Score: 0.177

Data Source: BioPlex,STRINGDB

NKAIN1

Tdark

Family: Enzyme

Novelty: 0.52190272

p_int: 0.999898564

p_ni: 0.000101434

p_wrong: 2e-9

Data Source: BioPlex

PNLDC1

Tbio

Family: Enzyme

Novelty: 0.16308361

p_int: 0.999728476

p_ni: 0.000271169

p_wrong: 3.55e-7

Score: 0.187

Data Source: BioPlex,STRINGDB

ZACN

Tchem

Family: IC

Novelty: 0.21891621

p_int: 0.999592189

p_ni: 0.000407627

p_wrong: 1.84e-7

Data Source: BioPlex

PSCA

Tbio

Novelty: 0.00323778

p_int: 0.998873269

p_ni: 0.001125543

p_wrong: 0.000001187

Data Source: BioPlex

EIF2B5

Tbio

Novelty: 0.0102209

p_int: 0.996361785

p_ni: 0.003123939

p_wrong: 0.000514275

Data Source: BioPlex

PTP4A1

Tchem

Family: Enzyme

Novelty: 0.02863007

p_int: 0.991248573

p_ni: 0.004631809

p_wrong: 0.004119618

Data Source: BioPlex

TRPV2

Tchem

Family: IC

Novelty: 0.00472952

Score: 0.954

Data Source: STRINGDB

Publication Statistics

PubMed Score  460.75

PubMed score by year

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PubTator Score  271.22

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Find similar targets by:

UniProt Keyword Find Similar Targets

Acetylation
Amyotrophic lateral sclerosis
ATP-binding
Calcium
Calcium channel
Calcium transport
Coiled coil
Complete proteome
Ion channel
Ion transport

GWAS Trait Find Similar Targets

household income
monocyte count

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cellular phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype