You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
TRPM7
Transient receptor potential cation channel subfamily M member 7

Protein Summary
Description
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313478
  • ENSP00000320239
  • ENSG00000092439
  • ENST00000646667
  • ENSP00000495860

Symbol
  • CHAK1
  • LTRPC7
  • CHAK
  • CHAK1
  • ALSPDC
  • LTRPC7
  • LTrpC-7
  • TRP-PLIK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cell type or tissue
0.92
histone modification site profile
0.84
transcription factor binding site profile
0.83
cell line
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 483.77   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 421   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 483.77   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (89)
ARL15
Tbio
Family:  Enzyme
Novelty:  0.09327102
p_int:  0.999999312
p_ni:  3.55e-7
p_wrong:  3.34e-7
Score:  0.264
Data Source:  BioPlex,STRINGDB
TEX28
Tdark
Novelty:  0.10581423
p_int:  0.999991451
p_ni:  0.000008548
p_wrong:  1e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.999957052
p_ni:  0.000042932
p_wrong:  1.6e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.999898564
p_ni:  0.000101434
p_wrong:  2e-9
Data Source:  BioPlex
PNLDC1
Tbio
Family:  Enzyme
Novelty:  0.16308361
p_int:  0.999728476
p_ni:  0.000271169
p_wrong:  3.55e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.999592189
p_ni:  0.000407627
p_wrong:  1.84e-7
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.998873269
p_ni:  0.001125543
p_wrong:  0.000001187
Data Source:  BioPlex
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.996361785
p_ni:  0.003123939
p_wrong:  0.000514275
Data Source:  BioPlex
PTP4A1
Tchem
Family:  Enzyme
Novelty:  0.02863007
p_int:  0.991248573
p_ni:  0.004631809
p_wrong:  0.004119618
Data Source:  BioPlex
TRPV2
Tchem
Family:  IC
Novelty:  0.00472952
Score:  0.954
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
91.6
leukocyte count
2
2
2
88.3
neutrophil count
2
2
2
86.4
total cholesterol measurement
1
2
2
82.4
fibrinogen measurement
4
4
4
72.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
91.6
leukocyte count
2
88.3
neutrophil count
2
86.4
total cholesterol measurement
2
82.4
fibrinogen measurement
4
72.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 7
VGNC:7522
453429
Macaque
transient receptor potential cation channel subfamily M member 7
716755
Mouse
MGI:1929996
58800
Rat
RGD:620053
679906
Dog
transient receptor potential cation channel subfamily M member 7
VGNC:47878
478300
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 7
Macaque
transient receptor potential cation channel subfamily M member 7
Mouse
Rat
Dog
transient receptor potential cation channel subfamily M member 7
Publication Statistics
PubMed Score 483.77
PubMed score by year
PubTator Score 271.22
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title