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Tbio
TSPAN32
Tetraspanin-32

Protein Summary
Description
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000182290
  • ENSP00000182290
  • ENSG00000064201
  • ENST00000381121
  • ENSP00000370513
  • ENST00000446063
  • ENSP00000395018

Symbol
  • PHEMX
  • TSSC6
  • ART1
  • PHMX
  • PHEMX
  • TSSC6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.72
tissue sample
0.67
gene perturbation
0.63
protein domain
0.58
small molecule perturbation
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
0
1.2
94.1
mean corpuscular hemoglobin concentration
1
1
1
81.4
basophil count
2
2
2
81
red blood cell density measurement
1
1
1
76.5
mean corpuscular volume
1
1
1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
94.1
mean corpuscular hemoglobin concentration
1
81.4
basophil count
2
81
red blood cell density measurement
1
76.5
mean corpuscular volume
1
72.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tetraspanin 32
704862
Mouse
MGI:1350360
27027
Rat
RGD:1308721
365390
Dog
tetraspanin 32
VGNC:47921
483667
Horse
tetraspanin 32 [Source:HGNC Symbol;Acc:HGNC:13410]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tetraspanin 32
Mouse
Rat
Dog
tetraspanin 32
Horse
tetraspanin 32 [Source:HGNC Symbol;Acc:HGNC:13410]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96QS1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (47)
1 – 10 of 47
TSSC4
Tdark
Novelty:  0.17064786
Score:  0.882
Data Source:  STRINGDB
TSPAN19
Tdark
Novelty:  0.92458543
Score:  0.773
Data Source:  STRINGDB
C11orf21
Tdark
Novelty:  0.45801604
Score:  0.724
Data Source:  STRINGDB
TSPAN9
Tbio
Novelty:  0.17982192
Score:  0.692
Data Source:  STRINGDB
ZNF215
Tdark
Family:  TF
Novelty:  0.19814973
Score:  0.68
Data Source:  STRINGDB
CD151
Tbio
Novelty:  0.00295527
Score:  0.667
Data Source:  STRINGDB
PRRT1
Tbio
Novelty:  0.08707857
Score:  0.657
Data Source:  STRINGDB
TSPAN15
Tbio
Novelty:  0.16947672
Score:  0.649
Data Source:  STRINGDB
TSPAN16
Tbio
Novelty:  0.00452657
Score:  0.645
Data Source:  STRINGDB
PHLDA2
Tbio
Novelty:  0.01847579
Score:  0.64
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.69

PubMed score by year
PubTator Score  4.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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