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Tbio
ALPK1
Alpha-protein kinase 1

Protein Summary
Description
Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161). This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000177648
  • ENSP00000177648
  • ENSG00000073331
  • ENST00000458497
  • ENSP00000398048
  • ENST00000504176
  • ENSP00000426044

Symbol
  • KIAA1527
  • LAK
  • LAK
  • 8430410J10Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
small molecule perturbation
0.67
virus perturbation
0.64
trait
0.61
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.67   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.67   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (32)
1 – 10 of 32
SCGB1D2
Tbio
Novelty:  0.02178942
p_int:  0.988331457
p_ni:  0.009854829
p_wrong:  0.001813713
Score:  0.622
Data Source:  BioPlex,STRINGDB
MYO1A
Tbio
Novelty:  0.00942771
Score:  0.826
Data Source:  STRINGDB
MYLK
Tchem
Family:  Kinase
Novelty:  0.00102277
Score:  0.663
Data Source:  STRINGDB
MYO1B
Tbio
Novelty:  0.00761267
Score:  0.641
Data Source:  STRINGDB
ALPK2
Tbio
Family:  Kinase
Novelty:  0.0442897
Score:  0.59
Data Source:  STRINGDB
ALPK3
Tdark
Family:  Kinase
Novelty:  0.04808875
Score:  0.587
Data Source:  STRINGDB
SLC22A12
Tclin
Family:  Transporter
Novelty:  0.00318081
Score:  0.57
Data Source:  STRINGDB
AP1AR
Tbio
Novelty:  0.01660994
Score:  0.541
Data Source:  STRINGDB
ZGRF1
Tdark
Novelty:  0.38769552
Score:  0.534
Data Source:  STRINGDB
ALOXE3
Tbio
Family:  Enzyme
Novelty:  0.02560954
Score:  0.513
Data Source:  STRINGDB
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
78
lymphocyte percentage of leukocytes
1
1
1
73.7
body mass index
4
2
4
54.2
1
1
0
1.1
26.1
body height
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
78
lymphocyte percentage of leukocytes
1
73.7
body mass index
4
54.2
0
1.1
26.1
body height
1
24.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha kinase 1
VGNC:2948
471280
Macaque
alpha kinase 1
700993
Mouse
MGI:1918731
71481
Rat
RGD:1304613
310879
Dog
alpha kinase 1
VGNC:37815
487906
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha kinase 1
Macaque
alpha kinase 1
Mouse
Rat
Dog
alpha kinase 1
Publication Statistics
PubMed Score 36.67
PubMed score by year
PubTator Score 263.23
PubTator score by year
Patents
Patents by year