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Tbio
VPS35
Vacuolar protein sorting-associated protein 35

Protein Classes
Protein Summary
Description
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.98
kinase perturbation
0.97
virus perturbation
0.96
histone modification site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.82   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.82   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
WNT ligand biogenesis and trafficking
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by WNT
WNT ligand biogenesis and trafficking
Gene Ontology Terms (60)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (215)
1 – 10 of 215
VPS26A
Tbio
Novelty: 0.01804654
p_int: 0.999997494
p_ni: 0.000002506
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
VPS29
Tbio
Novelty: 0.01335106
p_int: 0.999997485
p_ni: 0.000002515
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
VPS26B
Tdark
Novelty: 0.25702869
p_int: 0.999988817
p_ni: 0.000011183
Score: 0.999
Data Source: BioPlex,STRINGDB
MCM7
Tbio
Novelty: 0.0017984
p_int: 0.999420531
p_ni: 0.000579469
Score: 0.819
Data Source: BioPlex,STRINGDB
SNX3
Tbio
Novelty: 0.02703152
p_int: 0.996229081
p_ni: 0.003770918
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LRRC73
Tdark
Novelty: 48
p_int: 0.977962451
p_ni: 0.02203622
p_wrong: 0.000001329
Data Source: BioPlex
MRM1
Tbio
Family: Enzyme
Novelty: 0.08762499
p_int: 0.938043631
p_ni: 0.061956369
Score: 0.588
Data Source: BioPlex,STRINGDB
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.758992289
p_ni: 0.2410077
p_wrong: 1.1e-8
Data Source: BioPlex
SNX2
Tbio
Novelty: 0.03880384
Score: 0.999
Data Source: STRINGDB
SNX1
Tbio
Novelty: 0.01267973
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  150.82

PubMed score by year
PubTator Score  93.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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