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Tdark
HS3ST6
Heparan sulfate glucosamine 3-O-sulfotransferase 6

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293937
  • ENSP00000293937
  • ENSG00000276333
  • ENST00000454677
  • ENSP00000416741
  • ENSG00000162040

Symbol
  • HS3ST5
  • HS3ST5
  • 3-OST-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.65
cellular component
0.61
cell type or tissue
0.52
cell line
0.5
PubMedID
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.81   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.81   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0