MTMR9
Myotubularin-related protein 9
Protein Classes
Protein Summary
Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential). This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. [provided by RefSeq, Jul 2008]
- ENST00000221086
- ENSP00000221086
- ENSG00000104643
- ENST00000526292
- ENSP00000433239
- C8orf9
- MTMR8
- MTMR8
- C8orf9
- LIP-STYX
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.95 | ||
transcription factor perturbation | 0.91 | ||
transcription factor binding site profile | 0.89 | ||
virus perturbation | 0.88 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.95 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 108 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.95 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 108 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
extraversion | 1 | 1 | 1 | 47 | |||||
neuroticism measurement | 1 | 1 | 1 | 19.4 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
extraversion | 1 | 47 | |||||
neuroticism measurement | 1 | 19.4 | |||||
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myotubularin related protein 9 | 472697 | ||||||
Macaque | myotubularin related protein 9 | 697490 | ||||||
Mouse | MGI:2442842 | 210376 | ||||||
Rat | RGD:628840 | 282584 | ||||||
Dog | myotubularin related protein 9 | VGNC:43488 | 607147 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | myotubularin related protein 9 | |||||
Macaque | myotubularin related protein 9 | |||||
Mouse | ||||||
Rat | ||||||
Dog | myotubularin related protein 9 | |||||
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Inositol phosphate metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PI Metabolism | ||||
Reactome | Phospholipid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Inositol phosphate metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
PI Metabolism | ||||
Phospholipid metabolism | ||||
Gene Ontology Terms (12)
Functions (4)
Components (3)
Processes (5)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (61)
1 – 10 of 61
MTMR7
Family: Enzyme
Novelty: 0.1707096
p_int: 1
Score: 0.984
Data Source: BioPlex,Reactome,STRINGDB
MTMR2
Family: Enzyme
Novelty: 0.01403122
p_int: 0.999999948
p_ni: 5.2e-8
Score: 0.223
Data Source: BioPlex,STRINGDB
MTMR8
Family: Enzyme
Novelty: 0.37417853
p_int: 0.999996495
p_ni: 0.000003501
p_wrong: 4e-9
Score: 0.984
Data Source: BioPlex,Reactome,STRINGDB
MTMR6
Family: Enzyme
Novelty: 0.13067072
p_int: 0.999994386
p_ni: 0.000005614
p_wrong: 1e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
CDA
Family: Enzyme
Novelty: 0.00280981
p_int: 0.999845015
p_ni: 0.000154566
p_wrong: 4.19e-7
Score: 0.747
Data Source: BioPlex,STRINGDB
KCTD17
Novelty: 0.12105733
p_int: 0.99971478
p_ni: 0.000271813
p_wrong: 0.000013407
Score: 0.223
Data Source: BioPlex,STRINGDB
CTSE
Family: Enzyme
Novelty: 0.00432129
p_int: 0.999598921
p_ni: 0.000388403
p_wrong: 0.000012676
Score: 0.679
Data Source: BioPlex,STRINGDB
TTR
Novelty: 0.0001199
p_int: 0.999502406
p_ni: 0.000497594
Data Source: BioPlex
ZC3H3
Novelty: 0.26894046
p_int: 0.998726846
p_ni: 0.001212315
p_wrong: 0.000060839
Data Source: BioPlex
EMP3
Novelty: 0.03253214
p_int: 0.994776848
p_ni: 0.005223152
Data Source: BioPlex
Publication Statistics
PubMed Score 11.95
PubMed score by year
PubTator Score 4.34
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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