Tbio MTMR9 Myotubularin-related protein 9

Protein Summary

Description

Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential). This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96QG7
• B7Z291
• Q52LU3
• Q8WW11
• Q96QG6
• Q9NX50

Gene Name

• MTMR9

Ensembl ID

• ENST00000221086
• ENSP00000221086
• ENSG00000104643
• ENST00000526292
• ENSP00000433239

Symbol

• C8orf9
• MTMR8
• MTMR8
• C8orf9
• LIP-STYX

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.95
transcription factor perturbation	0.91
transcription factor binding site profile	0.89
virus perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Myotubularin-related Protein 9

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Myotubularin-related Protein 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (61)

Explore Interacting Targets

1 – 10 of 61

• See Interactions on String-DB

MTMR7

Tbio

Family:  Enzyme

Novelty:  0.1707096

p_int:  1

Score:  0.984

Data Source:  BioPlex,Reactome,STRINGDB

MTMR2

Tbio

Family:  Enzyme

Novelty:  0.01403122

p_int:  0.999999948

p_ni:  5.2e-8

Score:  0.223

Data Source:  BioPlex,STRINGDB

MTMR8

Tbio

Family:  Enzyme

Novelty:  0.37417853

p_int:  0.999996495

p_ni:  0.000003501

p_wrong:  4e-9

Score:  0.984

Data Source:  BioPlex,Reactome,STRINGDB

MTMR6

Tbio

Family:  Enzyme

Novelty:  0.13067072

p_int:  0.999994386

p_ni:  0.000005614

p_wrong:  1e-9

Score:  0.987

Data Source:  BioPlex,Reactome,STRINGDB

CDA

Tclin

Family:  Enzyme

Novelty:  0.00280981

p_int:  0.999845015

p_ni:  0.000154566

p_wrong:  4.19e-7

Score:  0.747

Data Source:  BioPlex,STRINGDB

KCTD17

Tbio

Novelty:  0.12105733

p_int:  0.99971478

p_ni:  0.000271813

p_wrong:  0.000013407

Score:  0.223

Data Source:  BioPlex,STRINGDB

CTSE

Tchem

Family:  Enzyme

Novelty:  0.00432129

p_int:  0.999598921

p_ni:  0.000388403

p_wrong:  0.000012676

Score:  0.679

Data Source:  BioPlex,STRINGDB

TTR

Tclin

Novelty:  0.0001199

p_int:  0.999502406

p_ni:  0.000497594

Data Source:  BioPlex

ZC3H3

Tbio

Novelty:  0.26894046

p_int:  0.998726846

p_ni:  0.001212315

p_wrong:  0.000060839

Data Source:  BioPlex

EMP3

Tbio

Novelty:  0.03253214

p_int:  0.994776848

p_ni:  0.005223152

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (8)

Inositol phosphate metabolism (R-HSA-1483249)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Inositol phosphate metabolism	48 targets	R-HSA-1483249
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	PI Metabolism	83 targets	R-HSA-1483255
Reactome	Phospholipid metabolism	211 targets	R-HSA-1483257

Name	Explore in Pharos	Explore in Source
Inositol phosphate metabolism	48 targets	R-HSA-1483249
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
PI Metabolism	83 targets	R-HSA-1483255
Phospholipid metabolism	211 targets	R-HSA-1483257

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (4)

Components (3)

Processes (5)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
protein phosphatase binding	Inferred from Physical Interaction (IPI)	UniProtKB
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	Traceable Author Statement (TAS)	Reactome
phosphatidylinositol-3-phosphatase activity	Traceable Author Statement (TAS)	Reactome
enzyme regulator activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (17)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neuroticism measurement	EFO_0007660	4	14	15		96.6
waist-hip ratio	EFO_0004343	1	10	10		79.6
BMI-adjusted waist-hip ratio	EFO_0007788	1	9	9		76.4
BMI-adjusted waist circumference	EFO_0007789	2	9	9		76.2
waist circumference	EFO_0004342	2	7	7		70

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neuroticism measurement	EFO_0007660	15		96.6
waist-hip ratio	EFO_0004343	10		79.6
BMI-adjusted waist-hip ratio	EFO_0007788	9		76.4
BMI-adjusted waist circumference	EFO_0007789	9		76.2
waist circumference	EFO_0004342	7		70

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
comparative body size at age 10, self-reported
cortical surface area measurement
diet measurement
extraversion
heel bone mineral density
mathematical ability
neuroticism measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myotubularin related protein 9		472697
Macaque	myotubularin related protein 9		697490
Mouse	myotubularin related protein 9	MGI:2442842	210376
Rat	myotubularin related protein 9	RGD:628840	282584
Dog	myotubularin related protein 9	VGNC:43488	607147

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myotubularin related protein 9
Macaque	myotubularin related protein 9
Mouse	myotubularin related protein 9
Rat	myotubularin related protein 9
Dog	myotubularin related protein 9

Publication Statistics

PubMed Score 12.02

PubMed score by year

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PubTator Score 4.34

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (6)

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10

0 of 0

PMID	Year	Title