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Tbio
MTMR9
Myotubularin-related protein 9

Protein Summary
Description
Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential). This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221086
  • ENSP00000221086
  • ENSG00000104643
  • ENST00000526292
  • ENSP00000433239

Symbol
  • C8orf9
  • MTMR8
  • MTMR8
  • C8orf9
  • LIP-STYX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
transcription factor perturbation
0.91
transcription factor binding site profile
0.89
virus perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
extraversion
1
1
1
47
neuroticism measurement
1
1
1
19.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
extraversion
1
47
neuroticism measurement
1
19.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 9
472697
Macaque
myotubularin related protein 9
697490
Mouse
MGI:2442842
210376
Rat
RGD:628840
282584
Dog
myotubularin related protein 9
VGNC:43488
607147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 9
Macaque
myotubularin related protein 9
Mouse
Rat
Dog
myotubularin related protein 9
Pathways (8)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Protein-Protein Interactions (61)
1 – 10 of 61
MTMR7
Tbio
Family: Enzyme
Novelty: 0.1707096
p_int: 1
Score: 0.984
Data Source: BioPlex,Reactome,STRINGDB
MTMR2
Tbio
Family: Enzyme
Novelty: 0.01403122
p_int: 0.999999948
p_ni: 5.2e-8
Score: 0.223
Data Source: BioPlex,STRINGDB
MTMR8
Tbio
Family: Enzyme
Novelty: 0.37417853
p_int: 0.999996495
p_ni: 0.000003501
p_wrong: 4e-9
Score: 0.984
Data Source: BioPlex,Reactome,STRINGDB
MTMR6
Tbio
Family: Enzyme
Novelty: 0.13067072
p_int: 0.999994386
p_ni: 0.000005614
p_wrong: 1e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
CDA
Tchem
Family: Enzyme
Novelty: 0.00280981
p_int: 0.999845015
p_ni: 0.000154566
p_wrong: 4.19e-7
Score: 0.747
Data Source: BioPlex,STRINGDB
KCTD17
Tbio
Novelty: 0.12105733
p_int: 0.99971478
p_ni: 0.000271813
p_wrong: 0.000013407
Score: 0.223
Data Source: BioPlex,STRINGDB
CTSE
Tchem
Family: Enzyme
Novelty: 0.00432129
p_int: 0.999598921
p_ni: 0.000388403
p_wrong: 0.000012676
Score: 0.679
Data Source: BioPlex,STRINGDB
TTR
Tclin
Novelty: 0.0001199
p_int: 0.999502406
p_ni: 0.000497594
Data Source: BioPlex
ZC3H3
Tbio
Novelty: 0.26894046
p_int: 0.998726846
p_ni: 0.001212315
p_wrong: 0.000060839
Data Source: BioPlex
EMP3
Tbio
Novelty: 0.03253214
p_int: 0.994776848
p_ni: 0.005223152
Data Source: BioPlex
Publication Statistics
PubMed Score  11.95

PubMed score by year
PubTator Score  4.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer