Tbio RAB3IP Rab-3A-interacting protein

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.

Uniprot Accession IDs

• Q96QF0
• B7WPJ6
• Q6PCE4
• Q96A24
• Q96QE6
• Q96QE7
• Q96QE8
• Q96QE9
• Q96QF1
• Q9H673
• Rab3A-interacting protein

Gene Name

• RAB3IP

Ensembl ID

• ENST00000247833
• ENSP00000247833
• ENSG00000127328
• ENST00000362025
• ENSP00000355381
• ENST00000378815
• ENSP00000368092
• ENST00000417413
• ENSP00000436304
• ENST00000483530
• ENSP00000419216
• ENST00000550536
• ENSP00000447300
• ENST00000551641
• ENSP00000448773
• ENST00000552199
• ENSP00000448944
• ENST00000553099
• ENSP00000448027

Symbol

• RABIN8
• RABIN3
• RABIN8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
transcription factor binding site profile	0.82
transcription factor	0.77
transcription factor perturbation	0.74
histone modification site profile	0.71

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Rab-3a-interacting Protein

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Rab-3a-interacting Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.03   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 170   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.03   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0