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Tbio
RAB3IP
Rab-3A-interacting protein

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247833
  • ENSP00000247833
  • ENSG00000127328
  • ENST00000362025
  • ENSP00000355381
  • ENST00000378815
  • ENSP00000368092
  • ENST00000417413
  • ENSP00000436304
  • ENST00000483530
  • ENSP00000419216
  • ENST00000550536
  • ENSP00000447300
  • ENST00000551641
  • ENSP00000448773
  • ENST00000552199
  • ENSP00000448944
  • ENST00000553099
  • ENSP00000448027

Symbol
  • RABIN8
  • RABIN3
  • RABIN8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor binding site profile
0.82
transcription factor
0.77
transcription factor perturbation
0.74
histone modification site profile
0.71


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB3A interacting protein
VGNC:5560
467209
Mouse
MGI:105933
216363
Rat
RGD:620650
29885
Dog
RAB3A interacting protein
VGNC:54536
481159
Horse
RAB3A interacting protein
100052332
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB3A interacting protein
Mouse
Rat
Dog
RAB3A interacting protein
Horse
RAB3A interacting protein
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Membrane Trafficking
Protein-Protein Interactions (222)
1 – 10 of 222
GDF5
Tbio
Novelty: 0.00218118
p_int: 0.999999808
p_ni: 1.85e-7
p_wrong: 7e-9
Score: 0.638
Data Source: BioPlex,STRINGDB
RAB3IL1
Tbio
Novelty: 0.0167537
p_int: 0.99999949
p_ni: 1e-9
p_wrong: 5.09e-7
Score: 0.726
Data Source: BioPlex,STRINGDB
PCMT1
Tbio
Family: Enzyme
Novelty: 0.01414946
p_int: 0.999859324
p_ni: 0.000004253
p_wrong: 0.000136423
Score: 0.171
Data Source: BioPlex,STRINGDB
CCDC146
Tdark
Novelty: 1.21651521
p_int: 0.999461868
p_ni: 0.000477882
p_wrong: 0.00006025
Score: 0.513
Data Source: BioPlex,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
p_int: 0.999167515
p_ni: 0.000482392
p_wrong: 0.000350093
Score: 0.179
Data Source: BioPlex,STRINGDB
ZC3H3
Tbio
Novelty: 0.26894046
p_int: 0.995518162
p_ni: 0.003400711
p_wrong: 0.001081127
Data Source: BioPlex
RAB8A
Tbio
Family: Enzyme
Novelty: 0.00486694
Score: 0.993
Data Source: Reactome,STRINGDB
RAB11A
Tbio
Family: Enzyme
Novelty: 0.00153551
Score: 0.99
Data Source: Reactome,STRINGDB
BBS1
Tbio
Novelty: 0.00939439
Score: 0.988
Data Source: STRINGDB
EXOC6
Tbio
Novelty: 0.01886811
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.81

PubMed score by year
PubTator Score  14.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer