Tbio TEFM Transcription elongation factor, mitochondrial

Protein Summary

Description

Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.

Uniprot Accession IDs

• Q96QE5
• E1P655
• Q6GPG5
• Q6PJ19
• Q96H04
• Q9H5Z9

Gene Name

• TEFM

Ensembl ID

• ENST00000306049
• ENSP00000306574
• ENSG00000172171
• ENST00000581216
• ENSP00000462963

Symbol

• C17orf42
• C17orf42

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor binding site profile	0.86
interacting protein	0.81
molecular function	0.73
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.01   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.01   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0