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Tbio
SLC2A13
Proton myo-inositol cotransporter

Protein Summary
Description
H(+)-myo-inositol cotransporter. Can also transport related stereoisomers.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280871
  • ENSP00000280871
  • ENSG00000151229

Symbol
  • HMIT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
histone modification site profile
0.78
transcription factor perturbation
0.74
transcription factor binding site profile
0.67
cell type or tissue
0.62


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.44   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.44   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
1
1.5
91.3
low density lipoprotein cholesterol measurement
2
2
2
61.3
mean platelet volume
1
1
1
36.9
1
1
0
1.5
32.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.5
91.3
low density lipoprotein cholesterol measurement
2
61.3
mean platelet volume
1
36.9
0
1.5
32.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 13
VGNC:8538
466953
Macaque
solute carrier family 2 member 13
697822
Mouse
MGI:2146030
239606
Rat
RGD:621814
171147
Dog
solute carrier family 2 member 13
VGNC:46340
486609
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 13
Macaque
solute carrier family 2 member 13
Mouse
Rat
Dog
solute carrier family 2 member 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96QE2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Inositol transporters (R-HSA-429593)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Inositol transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (165)
1 – 10 of 165
RIOK3
Tchem
Family:  Kinase
Novelty:  0.07513953
p_int:  0.999995102
p_ni:  0.000004822
p_wrong:  7.6e-8
Data Source:  BioPlex
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.874777766
p_ni:  0.125219205
p_wrong:  0.000003029
Data Source:  BioPlex
BLK
Tchem
Family:  Kinase
Novelty:  0.00480349
p_int:  0.815024164
p_ni:  0.180591899
p_wrong:  0.004383937
Data Source:  BioPlex
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
Score:  0.771
Data Source:  STRINGDB
POLR2J3
Tdark
Family:  Enzyme
Novelty:  0.96582106
Score:  0.771
Data Source:  STRINGDB
POLR2J2
Tdark
Family:  Enzyme
Novelty:  3.91016733
Score:  0.771
Data Source:  STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
Score:  0.757
Data Source:  STRINGDB
BUD13
Tbio
Novelty:  0.05228416
Score:  0.757
Data Source:  STRINGDB
POLR2C
Tbio
Family:  Enzyme
Novelty:  0.01652813
Score:  0.757
Data Source:  STRINGDB
SNW1
Tbio
Novelty:  0.01423797
Score:  0.757
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.44

PubMed score by year
PubTator Score  8.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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