Tbio SLC2A13 Proton myo-inositol cotransporter

Protein Classes

PANTHER Classes

Protein / ... / Carbohydrate Transporter / Proton Myo-inositol Cotransporter

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc2 Family Of Hexose And Sugar Alcohol Transporters / Proton-coupled Inositol Transporter / Proton Myo-inositol Cotransporter

Protein Summary

Description

H(+)-myo-inositol cotransporter. Can also transport related stereoisomers.

Uniprot Accession IDs

• Q96QE2
• Q17S07
• H(+)-myo-inositol cotransporter

Gene Name

• SLC2A13

Ensembl ID

• ENST00000280871
• ENSP00000280871
• ENSG00000151229

Symbol

• HMIT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
histone modification site profile	0.78
transcription factor perturbation	0.74
transcription factor binding site profile	0.67
cell type or tissue	0.62

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.44   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.44   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Parkinson's disease	EFO_0002508	3	3	1	1.5	91.3
low density lipoprotein cholesterol measurement	EFO_0004611	2	2	2		61.3
mean platelet volume	EFO_0004584	1	1	1		36.9
Crohn's disease	EFO_0000384	1	1	0	1.5	32.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Parkinson's disease	EFO_0002508	1	1.5	91.3
low density lipoprotein cholesterol measurement	EFO_0004611	2		61.3
mean platelet volume	EFO_0004584	1		36.9
Crohn's disease	EFO_0000384	0	1.5	32.7

Reset Zoom  Beta Count   Odds Ratio

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 2 member 13	VGNC:8538	466953
Macaque	solute carrier family 2 member 13		697822
Mouse	solute carrier family 2 (facilitated glucose transporter), member 13	MGI:2146030	239606
Rat	solute carrier family 2 member 13	RGD:621814	171147
Dog	solute carrier family 2 member 13	VGNC:46340	486609

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 2 member 13
Macaque	solute carrier family 2 member 13
Mouse	solute carrier family 2 (facilitated glucose transporter), member 13
Rat	solute carrier family 2 member 13
Dog	solute carrier family 2 member 13

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q96QE2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)

Reactome (4)

WikiPathways (2)

Inositol transporters (R-HSA-429593)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Inositol transporters	3 targets	R-HSA-429593
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Inositol transporters	3 targets	R-HSA-429593
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (4)

Functions (1)

Components (2)

Processes (1)

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10

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GO Term	Evidence	Assigned by
myo-inositol:proton symporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (165)

Explore Interacting Targets

1 – 10 of 165

• See Interactions on String-DB

RIOK3

Tchem

Family:  Kinase

Novelty:  0.07513953

p_int:  0.999995102

p_ni:  0.000004822

p_wrong:  7.6e-8

Data Source:  BioPlex

ATG9A

Tbio

Novelty:  0.01995033

p_int:  0.874777766

p_ni:  0.125219205

p_wrong:  0.000003029

Data Source:  BioPlex

BLK

Tchem

Family:  Kinase

Novelty:  0.00480349

p_int:  0.815024164

p_ni:  0.180591899

p_wrong:  0.004383937

Data Source:  BioPlex

POLR2J

Tbio

Family:  Enzyme

Novelty:  0.02344868

Score:  0.771

Data Source:  STRINGDB

POLR2J3

Tdark

Family:  Enzyme

Novelty:  0.96582106

Score:  0.771

Data Source:  STRINGDB

POLR2J2

Tdark

Family:  Enzyme

Novelty:  3.91016733

Score:  0.771

Data Source:  STRINGDB

POLR2E

Tbio

Family:  Enzyme

Novelty:  0.01817288

Score:  0.757

Data Source:  STRINGDB

BUD13

Tbio

Novelty:  0.05228416

Score:  0.757

Data Source:  STRINGDB

POLR2C

Tbio

Family:  Enzyme

Novelty:  0.01652813

Score:  0.757

Data Source:  STRINGDB

SNW1

Tbio

Novelty:  0.01423797

Score:  0.757

Data Source:  STRINGDB

Publication Statistics

PubMed Score  17.44

PubMed score by year

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PubTator Score  8.76

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

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Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport

GWAS Trait Find Similar Targets

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Crohn's disease
low density lipoprotein cholesterol measurement
mean platelet volume
Parkinson's disease

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype