Tbio SLC2A13 Proton myo-inositol cotransporter

Protein Classes

PANTHER Classes

Protein / ... / Carbohydrate Transporter / Proton Myo-inositol Cotransporter

Protein Summary

Description

H(+)-myo-inositol cotransporter. Can also transport related stereoisomers.

Uniprot Accession IDs

• Q96QE2
• Q17S07
• H(+)-myo-inositol cotransporter

Gene Name

• SLC2A13

Ensembl ID

• ENST00000280871
• ENSP00000280871
• ENSG00000151229

Symbol

• HMIT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
histone modification site profile	0.78
transcription factor perturbation	0.74
transcription factor binding site profile	0.67
cell type or tissue	0.62

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.26   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.26   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (6)

Reactome (4)

WikiPathways (2)

Inositol transporters (R-HSA-429593)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Inositol transporters	3 targets	R-HSA-429593
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Inositol transporters	3 targets	R-HSA-429593
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (4)

Functions (1)

Components (2)

Processes (1)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
myo-inositol:proton symporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (165)

Explore Interacting Targets

1 – 10 of 165

• See Interactions on String-DB

RIOK3

Tchem

Family: Kinase

Novelty: 0.07096405

p_int: 0.999995102

p_ni: 0.000004822

p_wrong: 7.6e-8

Data Source: BioPlex

ATG9A

Tbio

Novelty: 0.02725439

p_int: 0.874777766

p_ni: 0.125219205

p_wrong: 0.000003029

Data Source: BioPlex

BLK

Tchem

Family: Kinase

Novelty: 0.00922757

p_int: 0.815024164

p_ni: 0.180591899

p_wrong: 0.004383937

Data Source: BioPlex

POLR2J

Tbio

Family: Enzyme

Novelty: 0.03501746

Score: 0.771

Data Source: STRINGDB

POLR2J3

Tdark

Family: Enzyme

Novelty: 2

Score: 0.771

Data Source: STRINGDB

POLR2J2

Tdark

Family: Enzyme

Novelty: 2

Score: 0.771

Data Source: STRINGDB

POLR2E

Tbio

Family: Enzyme

Novelty: 0.02478824

Score: 0.757

Data Source: STRINGDB

BUD13

Tbio

Novelty: 0.06933519

Score: 0.757

Data Source: STRINGDB

POLR2C

Tbio

Family: Enzyme

Novelty: 0.03387776

Score: 0.757

Data Source: STRINGDB

SNW1

Tbio

Novelty: 0.01975138

Score: 0.757

Data Source: STRINGDB

Publication Statistics

PubMed Score  13.26

PubMed score by year

Reset Zoom

PubTator Score  8.76

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MSRKASENVEYTLRSLSSLMGERRRKQPEPDAASAAGECSLLAAAESSTSLQSAGAGGGGVGDLERAARR

1-70

QFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGA

70-140

LNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVT

140-210

INTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILS

210-280

QMRGNQTIDEEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSAT

280-350

ILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILALGFVLSAQVSP

350-420

RITFKPIAPSGQNATCTRYSYCNECMLDPDCGFCYKMNKSTVIDSSCVPVNKASTNEAAWGRCENETKFK

420-490

TEDIFWAYNFCPTPYSWTALLGLILYLVFFAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVS

490-560

LTFLHTAEYLTYYGAFFLYAGFAAVGLLFIYGCLPETKGKKLEEIESLFDNRLCTCGTSDSDEGRYIEYI

560-630

RVKGSNYHLSDNDASDVE

630-648

MSRKASENVEYTLRSLSSLMGERRRKQPEPDAASAAGECSLLAAAESSTSLQSAGAGGGGVGDLERAARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILALGFVLSAQVSPRITFKPIAPSGQNATCTRYSYCNECMLDPDCGFCYKMNKSTVIDSSCVPVNKASTNEAAWGRCENETKFKTEDIFWAYNFCPTPYSWTALLGLILYLVFFAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHTAEYLTYYGAFFLYAGFAAVGLLFIYGCLPETKGKKLEEIESLFDNRLCTCGTSDSDEGRYIEYIRVKGSNYHLSDNDASDVE

Find similar targets by:

Uniprot Keyword

Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport