Tbio PPP1R10 Serine/threonine-protein phosphatase 1 regulatory subunit 10

Protein Summary

Description

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q96QC0
• O00405

Gene Name

• PPP1R10

Ensembl ID

• ENST00000376511
• ENSP00000365694
• ENSG00000204569
• ENST00000383586
• ENSP00000373080
• ENSG00000206489
• ENST00000420949
• ENSP00000413554
• ENSG00000230995
• ENST00000424446
• ENSP00000407181
• ENSG00000231737
• ENST00000426299
• ENSP00000389299
• ENSG00000235291
• ENST00000429597
• ENSP00000407310
• ENSG00000238104
• ENST00000449113
• ENSP00000416060
• ENSG00000227804

Symbol

• CAT53
• FB19
• PNUTS
• p99
• FB19
• R111
• CAT53
• PNUTS
• PP1R10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
drug perturbation	0.71
cell line	0.66
microRNA	0.65
molecular function	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.76   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.76   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0