Tbio DLC1 Rho GTPase-activating protein 7

Protein Summary

Description

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q96QB1
• B4DR10
• B8PTI0
• E9PDZ8
• E9PF76
• E9PGY9
• O14868
• O43199
• Q7Z5R8
• Q86UC6
• Q9C0E0
• Q9H7A2

Gene Name

• DLC1

Ensembl ID

• ENST00000276297
• ENSP00000276297
• ENSG00000164741
• ENST00000316609
• ENSP00000321034
• ENST00000358919
• ENSP00000351797
• ENST00000511869
• ENSP00000425878
• ENST00000512044
• ENSP00000422595
• ENST00000520226
• ENSP00000428028
• ENST00000644385
• ENSP00000495134
• ENSG00000285265
• ENST00000645814
• ENSP00000496212

Symbol

• ARHGAP7
• KIAA1723
• STARD12
• HP
• ARHGAP7
• STARD12
• p122-RhoGAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
biological process	0.94
microRNA	0.93
small molecule perturbation	0.86
trait	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.63   (req: < 5)

Gene RIFs: 147   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.63   (req: >= 5)

Gene RIFs: 147   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0