Tbio GSDMA Gasdermin-A

Protein Summary

Description

May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).

Uniprot Accession IDs

• Q96QA5
• Q32MC5
• Q86VE7
• Q8N1M6

Gene Name

• GSDMA

Ensembl ID

• ENST00000301659
• ENSP00000301659
• ENSG00000167914
• ENST00000635792
• ENSP00000490739

Symbol

• GSDM
• GSDM1
• GSDM
• FKSG9
• GSDM1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.59
phenotype	0.58
tissue	0.5
disease	0.47
gene perturbation	0.46

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.53   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.53   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	3	3	0	1.2	91.2
childhood onset asthma	EFO_0004591	1	1	0	1.6	90.9
leukocyte count	EFO_0004308	1	1	1		78.3
age at onset	EFO_0004847	1	1	0	1.2	69.6
systemic scleroderma	EFO_0000717	1	1	1		59.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	0	1.2	91.2
childhood onset asthma	EFO_0004591	0	1.6	90.9
leukocyte count	EFO_0004308	1		78.3
age at onset	EFO_0004847	0	1.2	69.6
systemic scleroderma	EFO_0000717	1		59.6

Reset Zoom  Beta Count   Odds Ratio

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	gasdermin A	VGNC:9312	746070
Mouse	gasdermin A	MGI:1889509	57911
Rat	gasdermin A	RGD:1592062	360619
Dog	gasdermin A		608276
Horse	gasdermin A	VGNC:49300	100054598

Species	Name	OMA	EggNOG	Inparanoid
Chimp	gasdermin A
Mouse	gasdermin A
Rat	gasdermin A
Dog	gasdermin A
Horse	gasdermin A

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q96QA5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)

WikiPathways (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845

Name	Explore in Pharos	Explore in Source
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845

Gene Ontology Terms (8)

Functions (3)

Components (3)

Processes (2)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylinositol-4-phosphate binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylserine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (45)

Explore Interacting Targets

1 – 10 of 45

• See Interactions on String-DB

TEFM

Tbio

Novelty: 0.10836617

p_int: 0.990036302

p_ni: 0.009963698

Data Source: BioPlex

HES4

Tbio

Family: TF

Novelty: 0.05290912

p_int: 0.977457226

p_ni: 0.022542774

Data Source: BioPlex

ZIC1

Tbio

Family: TF

Novelty: 0.00491601

p_int: 0.966473707

p_ni: 0.033526293

Score: 0.198

Data Source: BioPlex,STRINGDB

TBC1D22B

Tbio

Novelty: 0.49852962

p_int: 0.948343436

p_ni: 0.051656561

p_wrong: 3e-9

Data Source: BioPlex

NDUFS5

Tclin

Family: Enzyme

Novelty: 0.13274675

p_int: 0.943973611

p_ni: 0.056026389

Data Source: BioPlex

ZSCAN12

Tdark

Family: TF

Novelty: 0.33578207

p_int: 0.927191258

p_ni: 0.072808742

Data Source: BioPlex

DDX19B

Tbio

Family: Enzyme

Novelty: 0.0504568

p_int: 0.860874656

p_ni: 0.139125344

Data Source: BioPlex

KLHL11

Tbio

Novelty: 0.1537041

p_int: 0.824565656

p_ni: 0.175434341

p_wrong: 2e-9

Data Source: BioPlex

GSDME

Tbio

Novelty: 0.01231123

Score: 0.807

Data Source: STRINGDB

ORMDL3

Tbio

Novelty: 0.00958976

Score: 0.764

Data Source: STRINGDB

Publication Statistics

PubMed Score  66.53

PubMed score by year

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PubTator Score  12.88

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Cell membrane
Complete proteome
Cytoplasm
Disulfide bond
Membrane
Necrosis
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

age at onset
asthma
childhood onset asthma
leukocyte count
lymphocyte percentage of leukocytes
monocyte percentage of leukocytes
myeloid white cell count
seasonal allergic rhinitis
systemic scleroderma