Protein Summary
May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).
- ENST00000301659
- ENSP00000301659
- ENSG00000167914
- ENST00000635792
- ENSP00000490739
- GSDM
- GSDM1
- GSDM
- FKSG9
- GSDM1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell line | 0.59 | ||
phenotype | 0.58 | ||
tissue | 0.5 | ||
disease | 0.47 | ||
gene perturbation | 0.46 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.09 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.09 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (1)
WikiPathways (1)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
Gene Ontology Terms (8)
Functions (3)
Components (3)
Processes (2)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (45)
1 – 10 of 45
TEFM
Novelty: 0.13341034
p_int: 0.990036302
p_ni: 0.009963698
Data Source: BioPlex
HES4
Family: TF
Novelty: 0.10402777
p_int: 0.977457226
p_ni: 0.022542774
Data Source: BioPlex
ZIC1
Family: TF
Novelty: 0.00309271
p_int: 0.966473707
p_ni: 0.033526293
Score: 0.198
Data Source: BioPlex,STRINGDB
TBC1D22B
Novelty: 6
p_int: 0.948343436
p_ni: 0.051656561
p_wrong: 3e-9
Data Source: BioPlex
NDUFS5
Family: Enzyme
Novelty: 0.59900166
p_int: 0.943973611
p_ni: 0.056026389
Data Source: BioPlex
ZSCAN12
Family: TF
Novelty: 0.40909091
p_int: 0.927191258
p_ni: 0.072808742
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.05099873
p_int: 0.860874656
p_ni: 0.139125344
Data Source: BioPlex
KLHL11
Novelty: 0.39728266
p_int: 0.824565656
p_ni: 0.175434341
p_wrong: 2e-9
Data Source: BioPlex
GSDME
Novelty: 0.01946224
Score: 0.807
Data Source: STRINGDB
ORMDL3
Novelty: 0.01336886
Score: 0.764
Data Source: STRINGDB
Publication Statistics
PubMed Score 33.09
PubMed score by year
PubTator Score 12.88
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDVLEPGSSP
1-70
SDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSVAPKALETVQERKLAADHPFL
70-140
KEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQL
140-210
MVKGKDEWDIPHICNDNMQTFPPGEKSGEEKVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSRVGQS
210-280
SLLSSLSKLLGKKKELQDLELALEGALDKGHEVTLEALPKDVLLSKEAVGAILYFVGALTELSEAQQKLL
280-350
VKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMW
350-420
DPDTLPRLCALYAGLSLLQQLTKAS
420-445
MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDVLEPGSSPSDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSVAPKALETVQERKLAADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPPGEKSGEEKVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALEGALDKGHEVTLEALPKDVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMWDPDTLPRLCALYAGLSLLQQLTKAS
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