Tbio GSDMA Gasdermin-A

Protein Summary

Description

May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).

Uniprot Accession IDs

• Q96QA5
• Q32MC5
• Q86VE7
• Q8N1M6

Gene Name

• GSDMA

Ensembl ID

• ENST00000301659
• ENSP00000301659
• ENSG00000167914
• ENST00000635792
• ENSP00000490739

Symbol

• GSDM
• GSDM1
• GSDM
• FKSG9
• GSDM1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.59
phenotype	0.58
tissue	0.5
disease	0.47
gene perturbation	0.46

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.09   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.09   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (1)

WikiPathways (1)

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845

Name	Explore in Pharos	Explore in Source
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845

Gene Ontology Terms (8)

Functions (3)

Components (3)

Processes (2)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylinositol-4-phosphate binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylserine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (45)

Explore Interacting Targets

1 – 10 of 45

• See Interactions on String-DB

TEFM

Tbio

Novelty: 0.13341034

p_int: 0.990036302

p_ni: 0.009963698

Data Source: BioPlex

HES4

Tbio

Family: TF

Novelty: 0.10402777

p_int: 0.977457226

p_ni: 0.022542774

Data Source: BioPlex

ZIC1

Tbio

Family: TF

Novelty: 0.00309271

p_int: 0.966473707

p_ni: 0.033526293

Score: 0.198

Data Source: BioPlex,STRINGDB

TBC1D22B

Tbio

Novelty: 6

p_int: 0.948343436

p_ni: 0.051656561

p_wrong: 3e-9

Data Source: BioPlex

NDUFS5

Tclin

Family: Enzyme

Novelty: 0.59900166

p_int: 0.943973611

p_ni: 0.056026389

Data Source: BioPlex

ZSCAN12

Tdark

Family: TF

Novelty: 0.40909091

p_int: 0.927191258

p_ni: 0.072808742

Data Source: BioPlex

DDX19B

Tbio

Family: Enzyme

Novelty: 0.05099873

p_int: 0.860874656

p_ni: 0.139125344

Data Source: BioPlex

KLHL11

Tdark

Novelty: 0.39728266

p_int: 0.824565656

p_ni: 0.175434341

p_wrong: 2e-9

Data Source: BioPlex

GSDME

Tbio

Novelty: 0.01946224

Score: 0.807

Data Source: STRINGDB

ORMDL3

Tbio

Novelty: 0.01336886

Score: 0.764

Data Source: STRINGDB

Publication Statistics

PubMed Score  33.09

PubMed score by year

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PubTator Score  12.88

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDVLEPGSSP

1-70

SDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSVAPKALETVQERKLAADHPFL

70-140

KEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQL

140-210

MVKGKDEWDIPHICNDNMQTFPPGEKSGEEKVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSRVGQS

210-280

SLLSSLSKLLGKKKELQDLELALEGALDKGHEVTLEALPKDVLLSKEAVGAILYFVGALTELSEAQQKLL

280-350

VKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMW

350-420

DPDTLPRLCALYAGLSLLQQLTKAS

420-445

MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDVLEPGSSPSDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSVAPKALETVQERKLAADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPPGEKSGEEKVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALEGALDKGHEVTLEALPKDVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMWDPDTLPRLCALYAGLSLLQQLTKAS

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Uniprot Keyword

Cell membrane
Complete proteome
Cytoplasm
Disulfide bond
Membrane
Necrosis
Polymorphism
Reference proteome