Pharos : Target Details

Tbio

Protein Summary

Description

May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).

Uniprot Accession IDs

Gene Name

GSDMA

Ensembl ID

ENST00000301659
ENSP00000301659
ENSG00000167914
ENST00000635792
ENSP00000490739

Symbol

GSDM
GSDM1
GSDM
FKSG9
GSDM1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.59

phenotype	0.58

tissue	0.5

disease	0.47

gene perturbation	0.46

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.53 (req: < 5)

Gene RIFs: 12 (req: <= 3)

View Gene RIFs

Antibodies: 98 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.53 (req: >= 5)

Gene RIFs: 12 (req: > 3)

Antibodies: 98 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (9)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
asthma	EFO_0000270	3	3	0	1.2	91.2

childhood onset asthma	EFO_0004591	1	1	0	1.6	90.9

leukocyte count	EFO_0004308	1	1	1		78.3

age at onset	EFO_0004847	1	1	0	1.2	69.6

systemic scleroderma	EFO_0000717	1	1	1		59.6

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
asthma	EFO_0000270	0	1.2	91.2

childhood onset asthma	EFO_0004591	0	1.6	90.9

leukocyte count	EFO_0004308	1		78.3

age at onset	EFO_0004847	0	1.2	69.6

systemic scleroderma	EFO_0000717	1		59.6

Beta Count

Odds Ratio

Pathways (1)

WikiPathways (1)

Items per page:

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845

Name	Explore in Pharos	Explore in Source
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845

Gene Ontology Terms (8)

Functions (3)

Components (3)

Processes (2)

Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

phosphatidylinositol-4-phosphate binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

phosphatidylserine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (45)

1 – 10 of 45

See Interactions on String-DB

TEFM

Tbio

Novelty: 0.10836617

p_int: 0.990036302

p_ni: 0.009963698

Data Source: BioPlex

HES4

Tbio

Family: TF

Novelty: 0.05290912

p_int: 0.977457226

p_ni: 0.022542774

Data Source: BioPlex

ZIC1

Tbio

Family: TF

Novelty: 0.00491601

p_int: 0.966473707

p_ni: 0.033526293

Score: 0.198

Data Source: BioPlex,STRINGDB

TBC1D22B

Tbio

Novelty: 0.49852962

p_int: 0.948343436

p_ni: 0.051656561

p_wrong: 3e-9

Data Source: BioPlex

NDUFS5

Tclin

Family: Enzyme

Novelty: 0.13274675

p_int: 0.943973611

p_ni: 0.056026389

Data Source: BioPlex

ZSCAN12

Tdark

Family: TF

Novelty: 0.33578207

p_int: 0.927191258

p_ni: 0.072808742

Data Source: BioPlex

DDX19B

Tbio

Family: Enzyme

Novelty: 0.0504568

p_int: 0.860874656

p_ni: 0.139125344

Data Source: BioPlex

KLHL11

Tbio

Novelty: 0.1537041

p_int: 0.824565656

p_ni: 0.175434341

p_wrong: 2e-9

Data Source: BioPlex

GSDME

Tbio

Novelty: 0.01231123

Score: 0.807

Data Source: STRINGDB

ORMDL3

Tbio

Novelty: 0.00958976

Score: 0.764

Data Source: STRINGDB

Publication Statistics

PubMed Score 66.53

PubMed score by year

PubTator Score 12.88

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword

GWAS Trait


Cell membrane

Complete proteome

Cytoplasm

Disulfide bond

Membrane

Necrosis

Polymorphism

Reference proteome