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Tbio
SLC4A9
Anion exchange protein 4

Protein Summary
Description
Probable apical anion exchanger of the kidney cortex. The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432095
  • ENSP00000410056
  • ENSG00000113073
  • ENST00000506545
  • ENSP00000422855
  • ENST00000506757
  • ENSP00000424424
  • ENST00000507527
  • ENSP00000427661

Symbol
  • AE4
  • SBC5
  • AE4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
cell type or tissue
0.76
protein domain
0.73
cell line
0.51
tissue sample
0.45


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.57   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.57   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
5
2
5.9
57.7
white matter integrity
2
1
2
35
creatine kinase measurement
1
1
1
31.4
worry measurement
1
1
0
5.7
24.5
reaction time measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
5.9
57.7
white matter integrity
2
35
creatine kinase measurement
1
31.4
worry measurement
0
5.7
24.5
reaction time measurement
1
5.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 9
VGNC:8646
462114
Macaque
solute carrier family 4 member 9
695782
Mouse
MGI:2443384
240215
Rat
RGD:628811
266612
Dog
solute carrier family 4 member 9
VGNC:46438
487162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 9
Macaque
solute carrier family 4 member 9
Mouse
Rat
Dog
solute carrier family 4 member 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96Q91-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Bicarbonate transporters (R-HSA-425381)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (30)
1 – 10 of 30
LIMS1
Tbio
Novelty:  0.00648304
Score:  0.654
Data Source:  STRINGDB
GYPA
Tbio
Novelty:  0.00067203
Score:  0.653
Data Source:  STRINGDB
ANKHD1
Tbio
Novelty:  0.05390096
Score:  0.618
Data Source:  STRINGDB
SLC26A3
Tbio
Family:  Transporter
Novelty:  0.00157687
Score:  0.602
Data Source:  STRINGDB
SLC26A6
Tbio
Family:  IC
Novelty:  0.00922143
Score:  0.581
Data Source:  STRINGDB
SLC26A7
Tbio
Family:  Transporter
Novelty:  0.03879487
Score:  0.573
Data Source:  STRINGDB
SLC26A4
Tbio
Family:  Transporter
Novelty:  0.00162006
Score:  0.57
Data Source:  STRINGDB
H1F0
Tchem
Novelty:  0.00039686
Score:  0.57
Data Source:  STRINGDB
EIF4EBP3
Tbio
Novelty:  0.12272754
Score:  0.547
Data Source:  STRINGDB
SLC26A9
Tbio
Family:  Transporter
Novelty:  0.0354738
Score:  0.513
Data Source:  STRINGDB
Publication Statistics
PubMed Score  51.57

PubMed score by year
PubTator Score  14.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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