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Tchem
ALKBH3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Protein Summary
Description
Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Also acts on RNA (PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196, PubMed:26863410). Require ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302708
  • ENSP00000302232
  • ENSG00000166199
  • ENST00000530803
  • ENSP00000436788

Symbol
  • ABH3
  • DEPC1
  • ABH3
  • PCA1
  • DEPC1
  • hABH3
  • DEPC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.88
histone modification site profile
0.84
transcription factor binding site profile
0.73
tissue sample
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.7   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.7   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
75.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
VGNC:6763
741336
Macaque
alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
715921
Mouse
MGI:1916363
69113
Rat
RGD:1359731
362169
Dog
alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
VGNC:37804
475938
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
Macaque
alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
Mouse
Rat
Dog
alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96Q83-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
ALKBH3 mediated reversal of alkylation damage (R-HSA-112126)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ALKBH3 mediated reversal of alkylation damage
Reactome
DNA Damage Reversal
Reactome
DNA Repair
Reactome
Reversal of alkylation damage by DNA dioxygenases
Name
Explore in Pharos
Explore in Source
ALKBH3 mediated reversal of alkylation damage
DNA Damage Reversal
DNA Repair
Reversal of alkylation damage by DNA dioxygenases
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
TRIP4
Tbio
Novelty: 0.06089355
p_int: 0.999958215
p_ni: 0.000041198
p_wrong: 5.87e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
NEU2
Tbio
Family: Enzyme
Novelty: 0.00460828
p_int: 0.999847993
p_ni: 0.000151979
p_wrong: 2.7e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
ASCC2
Tbio
Novelty: 0.12261896
p_int: 0.999780499
p_ni: 0.0002195
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
ASCC3
Tbio
Novelty: 0.1303631
p_int: 0.997859221
p_ni: 0.002140779
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
PPP4R3A
Tbio
Family: Enzyme
Novelty: 0.04234592
p_int: 0.946179499
p_ni: 0.053820454
p_wrong: 4.7e-8
Score: 0.303
Data Source: BioPlex,STRINGDB
ASCC1
Tbio
Novelty: 0.1280098
p_int: 0.92208485
p_ni: 0.07791515
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.874064654
p_ni: 0.125935346
Score: 0.193
Data Source: BioPlex,STRINGDB
ALKBH1
Tbio
Family: Enzyme
Novelty: 0.00504781
Score: 0.941
Data Source: STRINGDB
ALKBH8
Tbio
Novelty: 0.02797162
Score: 0.864
Data Source: STRINGDB
FTO
Tbio
Family: Enzyme
Novelty: 0.00053473
Score: 0.765
Data Source: STRINGDB
Publication Statistics
PubMed Score  50.70

PubMed score by year
PubTator Score  36.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer