You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DERL3
Derlin-3

Protein Classes
Protein Summary
Description
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976). May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318109
  • ENSP00000315303
  • ENSG00000099958
  • ENST00000406855
  • ENSP00000384744
  • ENST00000476077
  • ENSP00000419399
  • ENST00000620697
  • ENSP00000483693
  • ENSG00000274437
  • ENST00000628868
  • ENSP00000485763
  • ENST00000631305
  • ENSP00000486587

Symbol
  • C22orf14
  • DER3
  • LLN2
  • IZP6
  • LLN2
  • C22orf14
  • derlin-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.67
transcription factor
0.64
gene perturbation
0.59
tissue sample
0.54
PubMedID
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
5
5
96.3
serum gamma-glutamyl transferase measurement
2
5
5
96.3
serum IgG glycosylation measurement
1
1
1
82.8
serum IgG glycosylation measurement
1
1
1
82.8
serum non-albumin protein measurement
1
2
2
76.7
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
96.3
serum gamma-glutamyl transferase measurement
5
96.3
serum IgG glycosylation measurement
1
82.8
serum IgG glycosylation measurement
1
82.8
serum non-albumin protein measurement
2
76.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
derlin 3
699316
Mouse
MGI:1917627
70377
Rat
RGD:1597373
690315
Dog
derlin 3
VGNC:39904
486406
Cow
derlin 3
VGNC:28012
614334
Species
Name
OMA
EggNOG
Inparanoid
Macaque
derlin 3
Mouse
Rat
Dog
derlin 3
Cow
derlin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96Q80-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Defective CFTR causes cystic fibrosis
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Defective CFTR causes cystic fibrosis
Disease
Disorders of transmembrane transporters
Protein-Protein Interactions (86)
1 – 10 of 86
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
Score:  0.994
Data Source:  STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
Score:  0.978
Data Source:  STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.976
Data Source:  STRINGDB
ERLEC1
Tbio
Novelty:  0.01243855
Score:  0.964
Data Source:  STRINGDB
DERL1
Tbio
Novelty:  0.01382722
Score:  0.946
Data Source:  STRINGDB
SYVN1
Tbio
Family:  Enzyme
Novelty:  0.02216474
Score:  0.932
Data Source:  STRINGDB
ERLIN2
Tbio
Novelty:  0.04060163
Score:  0.931
Data Source:  STRINGDB
RNF5
Tbio
Family:  Enzyme
Novelty:  0.03015609
Score:  0.93
Data Source:  STRINGDB
ERLIN1
Tbio
Novelty:  0.06693859
Score:  0.927
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.925
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.67

PubMed score by year
PubTator Score  4.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: