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Tdark
TMEM237
Transmembrane protein 237

Protein Summary
Description
Component of the transition zone in primary cilia. Required for ciliogenesis. The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
histone modification site profile
0.87
cell line
0.67
tissue sample
0.62
microRNA
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.83   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.83   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (68)
1 – 10 of 68
EPX
Tbio
Family: Enzyme
Novelty: 0.00339273
p_int: 0.999991588
p_ni: 4.1e-8
p_wrong: 0.00000837
Score: 0.622
Data Source: BioPlex,STRINGDB
BPIFA1
Tbio
Novelty: 0.00586117
p_int: 0.999987032
p_ni: 0.00001237
p_wrong: 5.98e-7
Score: 0.28
Data Source: BioPlex,STRINGDB
RXFP1
Tchem
Family: GPCR
Novelty: 0.00580827
p_int: 0.999972831
p_ni: 0.00000492
p_wrong: 0.000022249
Data Source: BioPlex
IGHA2
Tbio
p_int: 0.999787782
p_ni: 0.000209517
p_wrong: 0.000002701
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999407951
p_ni: 0.000050314
p_wrong: 0.000541736
Data Source: BioPlex
BPIFB1
Tbio
Novelty: 0.03980683
p_int: 0.999067454
p_ni: 0.000932546
Score: 0.516
Data Source: BioPlex,STRINGDB
JCHAIN
Tbio
Novelty: 0.00172454
p_int: 0.996213586
p_ni: 0.001541811
p_wrong: 0.002244603
Score: 0.28
Data Source: BioPlex,STRINGDB
PIGR
Tbio
Novelty: 0.0025812
p_int: 0.995880052
p_ni: 0.004072866
p_wrong: 0.000047081
Score: 0.183
Data Source: BioPlex,STRINGDB
FGB
Tbio
Novelty: 0.00437751
p_int: 0.994403252
p_ni: 0.005590134
p_wrong: 0.000006614
Score: 0.211
Data Source: BioPlex,STRINGDB
IGHA1
Tbio
p_int: 0.990638173
p_ni: 0.009361827
Data Source: BioPlex
Publication Statistics
PubMed Score  3.83

PubMed score by year
PubTator Score  1.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer