You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ALS2
Alsin

Protein Summary
Description
May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264276
  • ENSP00000264276
  • ENSG00000003393
  • ENST00000467448
  • ENSP00000429223

Symbol
  • ALS2CR6
  • KIAA1563
  • ALSJ
  • PLSJ
  • IAHSP
  • ALS2CR6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
protein domain
0.92
transcription factor binding site profile
0.87
kinase perturbation
0.84
molecular function
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.43   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.43   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Gene Ontology Terms (38)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (79)
1 – 10 of 79
STXBP6
Tbio
Novelty: 0.18615646
p_int: 0.999999851
p_ni: 3.8e-8
p_wrong: 1.12e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.04657397
p_int: 0.999999315
p_ni: 6.84e-7
Score: 0.201
Data Source: BioPlex,STRINGDB
NEK1
Tchem
Family: Kinase
Novelty: 0.01999999
p_int: 0.999998737
p_ni: 0.000001263
Score: 0.473
Data Source: BioPlex,STRINGDB
SDF2
Tbio
Novelty: 0.0391791
p_int: 0.999983235
p_ni: 0.000016765
Score: 0.356
Data Source: BioPlex,STRINGDB
CFAP410
Tbio
Novelty: 0.00721386
p_int: 0.999524722
p_ni: 0.000474961
p_wrong: 3.17e-7
Score: 0.275
Data Source: BioPlex,STRINGDB
RBM6
Tbio
Novelty: 0.02740624
p_int: 0.985468192
p_ni: 0.014531362
p_wrong: 4.46e-7
Score: 0.231
Data Source: BioPlex,STRINGDB
ATG4C
Tbio
Family: Enzyme
Novelty: 0.00340552
p_int: 0.970737588
p_ni: 0.029262259
p_wrong: 1.53e-7
Data Source: BioPlex
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00149542
Score: 0.982
Data Source: STRINGDB
RAB5C
Tbio
Family: Enzyme
Novelty: 0.05493596
Score: 0.945
Data Source: STRINGDB
RAB5B
Tbio
Family: Enzyme
Novelty: 0.04098013
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  116.43

PubMed score by year
PubTator Score  75.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: