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Tchem
CDK15
Cyclin-dependent kinase 15

Protein Summary
Description
Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260967
  • ENSP00000260967
  • ENSG00000138395
  • ENST00000410091
  • ENSP00000386901
  • ENST00000434439
  • ENSP00000412775
  • ENST00000450471
  • ENSP00000406472

Symbol
  • ALS2CR7
  • PFTK2
  • PFTK2
  • ALS2CR7
  • PFTAIRE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
cellular component
0.75
protein domain
0.73
cell type or tissue
0.72
tissue
0.51


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL384304
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
5
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
95.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 15
VGNC:129
459880
Macaque
cyclin dependent kinase 15
703719
Mouse
MGI:3583944
271697
Rat
Dog
cyclin dependent kinase 15
VGNC:39047
478873
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 15
Macaque
cyclin dependent kinase 15
Mouse
Rat
Dog
cyclin dependent kinase 15
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96Q40-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (174)
1 – 10 of 174
ANXA8L1
Tbio
Novelty: 0.01847734
p_int: 0.999999966
p_ni: 3.4e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
S100A7A
Tbio
Novelty: 0.06518939
p_int: 0.999991139
p_ni: 0.000005626
p_wrong: 0.000003235
Data Source: BioPlex
FAM129B
Tbio
Novelty: 0.15635142
p_int: 0.999990726
p_ni: 0.000009086
p_wrong: 1.88e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
SDR16C5
Tbio
Family: Enzyme
Novelty: 0.11319496
p_int: 0.99998606
p_ni: 0.000013695
p_wrong: 2.45e-7
Data Source: BioPlex
PPL
Tbio
Novelty: 0.00684645
p_int: 0.999956545
p_ni: 0.000043455
Score: 0.164
Data Source: BioPlex,STRINGDB
SULT2B1
Tbio
Family: Enzyme
Novelty: 0.02652128
p_int: 0.999920972
p_ni: 0.000079012
p_wrong: 1.6e-8
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.999909158
p_ni: 0.000090842
Data Source: BioPlex
TYMP
Tclin
Family: Enzyme
Novelty: 0.0015906
p_int: 0.999897598
p_ni: 0.000102402
Score: 0.205
Data Source: BioPlex,STRINGDB
PYCARD
Tbio
Novelty: 0.00719985
p_int: 0.9998961
p_ni: 0.000103897
p_wrong: 3e-9
Data Source: BioPlex
TREX2
Tbio
Family: Enzyme
Novelty: 0.27214255
p_int: 0.999895575
p_ni: 0.000104425
Data Source: BioPlex
Publication Statistics
PubMed Score  3.11

PubMed score by year
PubTator Score  1.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer