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Tchem
SMG1
Serine/threonine-protein kinase SMG1

Protein Summary
Description
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000446231
  • ENSP00000402515
  • ENSG00000157106

Symbol
  • ATX
  • KIAA0421
  • LIP
  • ATX
  • LIP
  • 61E3.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
virus perturbation
0.97
microRNA
0.88
protein domain
0.85
small molecule perturbation
0.79


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.82   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.82   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
57.1
1
1
0
4.7
28.1
psychosis predisposition measurement
1
1
0
1.1
17.8
mean platelet volume
1
1
1
6.5
gut microbiome measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
57.1
0
4.7
28.1
psychosis predisposition measurement
0
1.1
17.8
mean platelet volume
1
6.5
gut microbiome measurement
1
0.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
VGNC:10344
453961
Mouse
MGI:1919742
233789
Dog
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
VGNC:46554
479832
Cow
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
VGNC:35010
525143
Opossum
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
100018609
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
Mouse
Dog
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
Cow
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
Opossum
SMG1, nonsense mediated mRNA decay associated PI3K related kinase
Protein Structure (0 Structures, 13 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (214)
1 – 10 of 214
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999999799
p_ni:  2.01e-7
Score:  0.277
Data Source:  BioPlex,STRINGDB
UPF2
Tbio
Novelty:  0.01064562
Score:  0.999
Data Source:  STRINGDB
UPF3A
Tbio
Novelty:  0.01431609
Score:  0.999
Data Source:  STRINGDB
RBM8A
Tbio
Novelty:  0.00052175
Score:  0.999
Data Source:  STRINGDB
SMG7
Tbio
Novelty:  0.03394393
Score:  0.999
Data Source:  STRINGDB
UPF3B
Tbio
Novelty:  0.03482348
Score:  0.999
Data Source:  STRINGDB
ETF1
Tbio
Family:  Enzyme
Novelty:  0.00711627
Score:  0.999
Data Source:  STRINGDB
EIF4A3
Tchem
Novelty:  0.00981496
Score:  0.999
Data Source:  STRINGDB
UPF1
Tbio
Novelty:  0.00311006
Score:  0.999
Data Source:  Reactome,STRINGDB
MAGOH
Tbio
Novelty:  0.03637008
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  112.82

PubMed score by year
PubTator Score  1756.98

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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