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Tbio
TRNT1
CCA tRNA nucleotidyltransferase 1, mitochondrial

Protein Summary
Description
Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro). The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251607
  • ENSP00000251607
  • ENSG00000072756
  • ENST00000280591
  • ENSP00000280591
  • ENST00000339437
  • ENSP00000342985
  • ENST00000402675
  • ENSP00000385745
  • ENST00000420393
  • ENSP00000400394
  • ENST00000434583
  • ENSP00000415100

Symbol
  • CCA1
  • RPEM
  • SIFD
  • MtCCA
  • CGI-47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
virus perturbation
0.92
histone modification site profile
0.85
tissue sample
0.73
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.28   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.28   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
NARS2
Tbio
Family:  Enzyme
Novelty:  0.01879317
p_int:  0.96431548
p_ni:  0.035683049
p_wrong:  0.000001471
Score:  0.37
Data Source:  BioPlex,STRINGDB
TRMT10C
Tbio
Family:  Enzyme
Novelty:  0.07045719
p_int:  0.935746155
p_ni:  0.064253845
Score:  0.67
Data Source:  BioPlex,STRINGDB
ACOT13
Tbio
Family:  Enzyme
Novelty:  0.04119879
Score:  0.876
Data Source:  STRINGDB
ELAC2
Tbio
Family:  Enzyme
Novelty:  0.01234318
Score:  0.84
Data Source:  STRINGDB
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
Score:  0.753
Data Source:  STRINGDB
YARS
Tchem
Family:  Enzyme
Novelty:  0.00302115
Score:  0.729
Data Source:  STRINGDB
TRIT1
Tbio
Family:  Enzyme
Novelty:  0.00296723
Score:  0.691
Data Source:  STRINGDB
PNPT1
Tbio
Family:  Enzyme
Novelty:  0.00339969
Score:  0.684
Data Source:  STRINGDB
FARS2
Tchem
Family:  Enzyme
Novelty:  0.00771459
Score:  0.641
Data Source:  STRINGDB
LARS2
Tbio
Family:  Enzyme
Novelty:  0.00543895
Score:  0.635
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the mitochondrion
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the mitochondrion
tRNA processing in the nucleus
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
5
7
98
eosinophil percentage of leukocytes
2
7
7
97.5
basophil percentage of leukocytes
2
6
7
94.6
basophil count
4
5
8
93.5
basophil percentage of granulocytes
1
3
3
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
7
98
eosinophil percentage of leukocytes
7
97.5
basophil percentage of leukocytes
7
94.6
basophil count
8
93.5
basophil percentage of granulocytes
3
91.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA nucleotidyl transferase 1
VGNC:10445
470735
Macaque
tRNA nucleotidyl transferase 1
704550
Mouse
MGI:1917297
70047
Rat
RGD:1308857
312616
Dog
tRNA nucleotidyl transferase 1
VGNC:47862
476552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA nucleotidyl transferase 1
Macaque
tRNA nucleotidyl transferase 1
Mouse
Rat
Dog
tRNA nucleotidyl transferase 1
Publication Statistics
PubMed Score 197.28
PubMed score by year
PubTator Score 24.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title