Tbio TRNT1 CCA tRNA nucleotidyltransferase 1, mitochondrial

Protein Summary

Description

Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro). The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q96Q11
• A8K2Z6
• B7WP13
• C9JKA2
• Q8ND57
• Q9BS97
• Q9Y362

Gene Name

• TRNT1

Ensembl ID

• ENST00000251607
• ENSP00000251607
• ENSG00000072756
• ENST00000280591
• ENSP00000280591
• ENST00000339437
• ENSP00000342985
• ENST00000402675
• ENSP00000385745
• ENST00000420393
• ENSP00000400394
• ENST00000434583
• ENSP00000415100

Symbol

• CCA1
• RPEM
• SIFD
• MtCCA
• CGI-47

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
virus perturbation	0.92
histone modification site profile	0.85
tissue sample	0.73
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.07   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.07   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0