BTBD9
BTB/POZ domain-containing protein 9
Protein Summary
This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]
- ENST00000314100
- ENSP00000323408
- ENSG00000183826
- ENST00000419706
- ENSP00000415365
- ENST00000481247
- ENSP00000418751
- ENST00000649492
- ENSP00000497066
- KIAA1880
- dJ322I12.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.92 | ||
protein domain | 0.85 | ||
microRNA | 0.84 | ||
transcription factor binding site profile | 0.78 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.26 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 110 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.26 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 110 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (107)
USP25
Family: Enzyme
Novelty: 0.03671706
p_int: 0.999065242
p_ni: 0.000934758
Score: 0.544
Data Source: BioPlex,STRINGDB
HSPB2
Novelty: 0.00103909
p_int: 0.996979629
p_ni: 0.003020371
p_wrong: 1e-9
Data Source: BioPlex
PPP1R21
Family: Enzyme
Novelty: 0.33099657
p_int: 0.986704446
p_ni: 0.013295554
Score: 0.183
Data Source: BioPlex,STRINGDB
PDIA6
Family: Enzyme
Novelty: 0.01692178
p_int: 0.980182618
p_ni: 0.019817382
Score: 0.199
Data Source: BioPlex,STRINGDB
UBXN1
Novelty: 0.10675958
p_int: 0.971576665
p_ni: 0.028423335
Score: 0.332
Data Source: BioPlex,STRINGDB
MSRB3
Family: Enzyme
Novelty: 0.02843512
p_int: 0.964570214
p_ni: 0.035429786
Score: 0.163
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
WikiPathways (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Sleep regulation | ||||
WikiPathways | Circadian rhythm related genes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Sleep regulation | ||||
Circadian rhythm related genes | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 4 | 0 | 1.6 | 98.7 | |||||
insomnia measurement | 1 | 3 | 0 | 1.1 | 85.2 | ||||
IGF-1 measurement | 1 | 1 | 1 | 66.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 53.3 | |||||
daytime rest measurement | 1 | 1 | 1 | 46.9 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.6 | 98.7 | |||||
insomnia measurement | 0 | 1.1 | 85.2 | ||||
IGF-1 measurement | 1 | 66.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 53.3 | |||||
daytime rest measurement | 1 | 46.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | BTB domain containing 9 | VGNC:7886 | 462661 | |||||
Macaque | BTB domain containing 9 | 719457 | ||||||
Mouse | MGI:1916625 | 224671 | ||||||
Rat | RGD:1306975 | 294318 | ||||||
Dog | BTB domain containing 9 | VGNC:52108 | 481777 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | BTB domain containing 9 | |||||
Macaque | BTB domain containing 9 | |||||
Mouse | ||||||
Rat | ||||||
Dog | BTB domain containing 9 | |||||
Publication Statistics
PubMed Score 40.26
PubMed score by year
PubTator Score 24.02
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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