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Tbio
BTBD9
BTB/POZ domain-containing protein 9

Protein Summary
Description
This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314100
  • ENSP00000323408
  • ENSG00000183826
  • ENST00000419706
  • ENSP00000415365
  • ENST00000481247
  • ENSP00000418751
  • ENST00000649492
  • ENSP00000497066

Symbol
  • KIAA1880
  • dJ322I12.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
protein domain
0.85
microRNA
0.84
transcription factor binding site profile
0.78
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.75   (req: < 5)
View Publications
Gene RIFs: 17   (req: <= 3)
View Gene RIFs
Antibodies: 110   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.75   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
restless legs syndrome
EFO_0004270
4
4
0
1.6
99.9
insomnia measurement
EFO_0007876
1
3
0
1.1
91
body mass index
EFO_0004340
1
1
1
65.8
mean corpuscular hemoglobin concentration
EFO_0004528
1
1
1
54.8
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
restless legs syndrome
EFO_0004270
0
1.6
99.9
insomnia measurement
EFO_0007876
0
1.1
91
body mass index
EFO_0004340
1
65.8
mean corpuscular hemoglobin concentration
EFO_0004528
1
54.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BTB domain containing 9
VGNC:7886
462661
Macaque
BTB domain containing 9
719457
Mouse
BTB (POZ) domain containing 9
MGI:1916625
224671
Rat
BTB domain containing 9
RGD:1306975
294318
Dog
BTB domain containing 9
VGNC:52108
481777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BTB domain containing 9
Macaque
BTB domain containing 9
Mouse
BTB (POZ) domain containing 9
Rat
BTB domain containing 9
Dog
BTB domain containing 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96Q07-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
adult locomotory behavior
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
circadian behavior
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
circadian sleep/wake cycle, non-REM sleep
Inferred from Electronic Annotation (IEA)
Ensembl
long-term memory
Inferred from Electronic Annotation (IEA)
Ensembl
multicellular organismal iron ion homeostasis
Inferred from Electronic Annotation (IEA)
Ensembl
regulation of synaptic vesicle endocytosis
Inferred from Electronic Annotation (IEA)
Ensembl
sensory perception of temperature stimulus
Inferred from Electronic Annotation (IEA)
Ensembl
serotonin metabolic process
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (107)
1 – 10 of 107
USP25
Tbio
Family: Enzyme
Novelty: 0.03671706
p_int: 0.999065242
p_ni: 0.000934758
Score: 0.544
Data Source: BioPlex,STRINGDB
FAM9B
Tdark
Novelty: 0.39508009
p_int: 0.998987486
p_ni: 0.001012514
Data Source: BioPlex
HSPB2
Tbio
Novelty: 0.00103909
p_int: 0.996979629
p_ni: 0.003020371
p_wrong: 1e-9
Data Source: BioPlex
SEPT3
Tbio
Novelty: 0.008513
p_int: 0.992794803
p_ni: 0.007205197
Data Source: BioPlex
PPP1R21
Tdark
Family: Enzyme
Novelty: 0.33099657
p_int: 0.986704446
p_ni: 0.013295554
Score: 0.183
Data Source: BioPlex,STRINGDB
LSM3
Tbio
Novelty: 0.05044984
p_int: 0.980955284
p_ni: 0.0190447
p_wrong: 1.6e-8
Data Source: BioPlex
PDIA6
Tchem
Family: Enzyme
Novelty: 0.01692178
p_int: 0.980182618
p_ni: 0.019817382
Score: 0.199
Data Source: BioPlex,STRINGDB
UBXN1
Tbio
Novelty: 0.10675958
p_int: 0.971576665
p_ni: 0.028423335
Score: 0.332
Data Source: BioPlex,STRINGDB
BSPRY
Tdark
Novelty: 0.38200913
p_int: 0.967419696
p_ni: 0.032580304
Data Source: BioPlex
MSRB3
Tbio
Family: Enzyme
Novelty: 0.02843512
p_int: 0.964570214
p_ni: 0.035429786
Score: 0.163
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  39.75

PubMed score by year
PubTator Score  24.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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