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Tchem
LMTK3
Serine/threonine-protein kinase LMTK3

Protein Summary
Description
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000600059
  • ENSP00000472020
  • ENSG00000142235

Symbol
  • KIAA1883
  • TYKLM3
  • LMR3
  • TYKLM3
  • PPP1R101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.73
tissue sample
0.65
histone modification site profile
0.61
cell type or tissue
0.54


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.79   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.79   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
2
86.6
lymphocyte percentage of leukocytes
1
1
1
81.5
neutrophil percentage of leukocytes
1
1
1
80.5
mathematical ability
2
1
2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
86.6
lymphocyte percentage of leukocytes
1
81.5
neutrophil percentage of leukocytes
1
80.5
mathematical ability
2
31.4
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lemur tyrosine kinase 3
VGNC:11167
100612219
Mouse
MGI:3039582
381983
Cow
lemur tyrosine kinase 3
VGNC:30942
100140306
Pig
lemur tyrosine kinase 3
100623034
Anole lizard
lemur tyrosine kinase 3
100560280
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lemur tyrosine kinase 3
Mouse
Cow
lemur tyrosine kinase 3
Pig
lemur tyrosine kinase 3
Anole lizard
lemur tyrosine kinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96Q04-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (23)
1 – 10 of 23
HOOK2
Tbio
Novelty:  0.03559628
Score:  0.703
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.577
Data Source:  STRINGDB
FRG2C
Tdark
Novelty:  0.85862622
Score:  0.554
Data Source:  STRINGDB
CUEDC2
Tbio
Novelty:  0.07403123
Score:  0.535
Data Source:  STRINGDB
RAB11FIP1
Tbio
Novelty:  0.0445306
Score:  0.505
Data Source:  STRINGDB
UBN2
Tbio
Novelty:  0.09777456
Score:  0.502
Data Source:  STRINGDB
ZNF594
Tdark
Family:  TF
Novelty:  4.84735349
Score:  0.499
Data Source:  STRINGDB
FREM3
Tdark
Novelty:  0.16573809
Score:  0.488
Data Source:  STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
Score:  0.461
Data Source:  STRINGDB
NUP210
Tbio
Novelty:  0.00784579
Score:  0.449
Data Source:  STRINGDB
Publication Statistics
PubMed Score  31.79

PubMed score by year
PubTator Score  21.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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