Tchem NEK1 Serine/threonine-protein kinase Nek1

Protein Summary

Description

Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q96PY6
• G5E9Z3
• Q05DG5
• Q14CB7
• Q5H9T1
• Q6PIB8
• Q96SS2
• Q9H6P7
• Q9Y594

Gene Name

• NEK1

Ensembl ID

• ENST00000439128
• ENSP00000408020
• ENSG00000137601
• ENST00000507142
• ENSP00000424757
• ENST00000510533
• ENSP00000427653
• ENST00000511633
• ENSP00000423332
• ENST00000512193
• ENSP00000424938

Symbol

• KIAA1901
• ALS24
• SRPS2
• SRTD6
• SRPS2A
• NY-REN-55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.96
molecular function	0.96
transcription factor perturbation	0.91
virus perturbation	0.88
transcription factor binding site profile	0.8

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Nek Family / Serine/threonine-protein Kinase Nek1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.01   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.01   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 165

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0