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Tchem
NEK1
Serine/threonine-protein kinase Nek1

Protein Summary
Description
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000439128
  • ENSP00000408020
  • ENSG00000137601
  • ENST00000507142
  • ENSP00000424757
  • ENST00000510533
  • ENSP00000427653
  • ENST00000511633
  • ENSP00000423332
  • ENST00000512193
  • ENSP00000424938

Symbol
  • KIAA1901
  • ALS24
  • SRPS2
  • SRTD6
  • SRPS2A
  • NY-REN-55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
molecular function
0.96
transcription factor perturbation
0.91
virus perturbation
0.88
transcription factor binding site profile
0.8


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.71   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.71   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 151
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 1
VGNC:6478
471345
Macaque
NIMA related kinase 1
694345
Mouse
MGI:97303
18004
Rat
RGD:1309375
290705
Dog
NIMA related kinase 1
VGNC:43729
486058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NIMA related kinase 1
Macaque
NIMA related kinase 1
Mouse
Rat
Dog
NIMA related kinase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96PY6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (20)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
CACAO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (88)
1 – 10 of 88
TTC25
Tdark
Novelty: 0.23064129
p_int: 0.999999751
p_ni: 2.49e-7
Score: 0.208
Data Source: BioPlex,STRINGDB
TEKT4
Tbio
Novelty: 0.05559086
p_int: 0.999999299
p_ni: 7.01e-7
Score: 0.218
Data Source: BioPlex,STRINGDB
ALS2
Tbio
Novelty: 0.0072324
p_int: 0.999998737
p_ni: 0.000001263
Score: 0.473
Data Source: BioPlex,STRINGDB
VPS26B
Tdark
Novelty: 0.25702869
p_int: 0.99999243
p_ni: 0.00000757
Score: 0.2
Data Source: BioPlex,STRINGDB
SKAP1
Tbio
Family: Enzyme
Novelty: 0.03753848
p_int: 0.999991422
p_ni: 0.000008578
Data Source: BioPlex
CPNE2
Tdark
Novelty: 0.24188419
p_int: 0.999989789
p_ni: 0.000010211
Data Source: BioPlex
WDR83
Tbio
Novelty: 0.11602568
p_int: 0.999810206
p_ni: 0.000189793
Data Source: BioPlex
KIF2B
Tbio
Novelty: 0.09958244
p_int: 0.968363949
p_ni: 0.031634069
p_wrong: 0.000001981
Score: 0.157
Data Source: BioPlex,STRINGDB
CTDSP2
Tbio
Family: Enzyme
Novelty: 0.01033594
p_int: 0.922174892
p_ni: 0.074947219
p_wrong: 0.002877889
Score: 0.159
Data Source: BioPlex,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
p_int: 0.864528689
p_ni: 0.116245427
p_wrong: 0.019225884
Score: 0.181
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  63.71

PubMed score by year
PubTator Score  29.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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