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Tchem
NEK1
Serine/threonine-protein kinase Nek1

Protein Summary
Description
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000439128
  • ENSP00000408020
  • ENSG00000137601
  • ENST00000507142
  • ENSP00000424757
  • ENST00000510533
  • ENSP00000427653
  • ENST00000511633
  • ENSP00000423332
  • ENST00000512193
  • ENSP00000424938

Symbol
  • KIAA1901
  • ALS24
  • SRPS2
  • SRTD6
  • SRPS2A
  • NY-REN-55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
molecular function
0.96
transcription factor perturbation
0.91
virus perturbation
0.88
transcription factor binding site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.01   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.01   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 165
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0