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Tbio
FMNL2
Formin-like protein 2

Protein Summary
Description
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288670
  • ENSP00000288670
  • ENSG00000157827

Symbol
  • FHOD2
  • KIAA1902
  • FHOD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor perturbation
0.91
ligand (protein) perturbation
0.83
virus perturbation
0.79
microRNA
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.8   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.8   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
USP48
Tbio
Family:  Enzyme
Novelty:  0.10103618
p_int:  0.999938366
p_ni:  7.73e-7
p_wrong:  0.000060861
Data Source:  BioPlex
S100A7A
Tbio
Novelty:  0.06518939
p_int:  0.999840045
p_ni:  0.000065306
p_wrong:  0.000094649
Data Source:  BioPlex
A2ML1
Tbio
Novelty:  0.05923067
p_int:  0.999533017
p_ni:  0.000466946
p_wrong:  3.7e-8
Data Source:  BioPlex
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.989095138
p_ni:  0.010904862
Score:  0.313
Data Source:  BioPlex,STRINGDB
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
p_int:  0.9673573
p_ni:  0.032639875
p_wrong:  0.000002825
Data Source:  BioPlex
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.957689661
p_ni:  0.042310339
Data Source:  BioPlex
POF1B
Tbio
Novelty:  0.1232792
p_int:  0.953174299
p_ni:  0.046825701
Data Source:  BioPlex
SERPINA3
Tbio
Novelty:  0.00134253
p_int:  0.896182194
p_ni:  0.103780426
p_wrong:  0.000037379
Data Source:  BioPlex
IVL
Tbio
Novelty:  0.00147892
p_int:  0.886664975
p_ni:  0.113333547
p_wrong:  0.000001479
Data Source:  BioPlex
ALOX12B
Tbio
Family:  Enzyme
Novelty:  0.02778552
p_int:  0.826748657
p_ni:  0.173251343
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Formins
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate Formins
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
3
6
91.2
heel bone mineral density
2
3
4
86
lymphocyte count
2
2
2
71.1
myeloid white cell count
1
1
1
68.3
leukocyte count
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
6
91.2
heel bone mineral density
4
86
lymphocyte count
2
71.1
myeloid white cell count
1
68.3
leukocyte count
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
formin like 2
VGNC:432
459663
Mouse
MGI:1918659
71409
Rat
RGD:1560248
499797
Horse
formin like 2
VGNC:18073
100050357
Cow
formin like 2
VGNC:29047
788312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
formin like 2
Mouse
Rat
Horse
formin like 2
Cow
formin like 2
Publication Statistics
PubMed Score 37.80
PubMed score by year
PubTator Score 21.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title