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Tbio
SLITRK1
SLIT and NTRK-like protein 1

Protein Summary
Description
It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509). This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377084
  • ENSP00000366288
  • ENSG00000178235

Symbol
  • KIAA1910
  • LRRC12
  • TTM
  • LRRC12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
cell line
0.68
microRNA
0.6
protein domain
0.58
transcription factor
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.38   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.38   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SLIT and NTRK like family member 1
VGNC:13146
467291
Macaque
SLIT and NTRK like family member 1
699217
Mouse
MGI:2679446
76965
Rat
RGD:1308858
306147
Dog
SLIT and NTRK like family member 1
VGNC:46506
485509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SLIT and NTRK like family member 1
Macaque
SLIT and NTRK like family member 1
Mouse
Rat
Dog
SLIT and NTRK like family member 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96PX8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Receptor-type tyrosine-protein phosphatases
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Receptor-type tyrosine-protein phosphatases
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO
Inferred from Direct Assay (IDA)
SynGO
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (90)
1 – 10 of 90
PTPRD
Tbio
Family: Enzyme
Novelty: 0.01059407
Score: 0.997
Data Source: STRINGDB
PTPRS
Tchem
Family: Enzyme
Novelty: 0.00587115
Score: 0.863
Data Source: STRINGDB
PTPRF
Tchem
Family: Enzyme
Novelty: 0.01017327
Score: 0.858
Data Source: STRINGDB
OPCML
Tbio
Novelty: 0.01569352
Score: 0.74
Data Source: STRINGDB
PTPRA
Tchem
Family: Enzyme
Novelty: 0.01392344
Score: 0.739
Data Source: STRINGDB
PTPRE
Tbio
Family: Enzyme
Novelty: 0.04184946
Score: 0.73
Data Source: STRINGDB
DLGAP3
Tbio
Novelty: 0.02019435
Score: 0.714
Data Source: STRINGDB
PTPRT
Tbio
Family: Enzyme
Novelty: 0.03394352
Score: 0.654
Data Source: STRINGDB
IGHMBP2
Tbio
Novelty: 0.01054517
Score: 0.645
Data Source: STRINGDB
SGCE
Tbio
Novelty: 0.00449577
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  78.38

PubMed score by year
PubTator Score  35.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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