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Tbio
SYNGAP1
Ras/Rap GTPase-activating protein SynGAP

Protein Summary
Description
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein int ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395071
  • ENSP00000378509
  • ENSG00000227460
  • ENST00000414753
  • ENSP00000407995
  • ENST00000418600
  • ENSP00000403636
  • ENSG00000197283
  • ENST00000428982
  • ENSP00000412475
  • ENST00000455687
  • ENSP00000414259
  • ENST00000628646
  • ENSP00000486431
  • ENST00000629380
  • ENSP00000486463
  • ENST00000646630
  • ENSP00000496007

Symbol
  • KIAA1938
  • MRD5
  • RASA1
  • RASA5
  • SYNGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.83
cell type or tissue
0.61
tissue sample
0.61
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 198.48   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 198.48   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.951
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.942
Data Source:  STRINGDB
SPRED1
Tbio
Novelty:  0.01050285
Score:  0.94
Data Source:  STRINGDB
NF1
Tbio
Novelty:  0.00019092
Score:  0.932
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.929
Data Source:  STRINGDB
RASA3
Tbio
Family:  Enzyme
Novelty:  0.03196973
Score:  0.928
Data Source:  STRINGDB
RASA2
Tdark
Family:  Enzyme
Novelty:  0.06658896
Score:  0.927
Data Source:  STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.925
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.925
Data Source:  STRINGDB
RASAL1
Tbio
Novelty:  0.02163608
Score:  0.925
Data Source:  STRINGDB
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
72.1
platelet count
2
2
2
72.1
3
3
0
1.1
66.5
3
3
0
1.1
66.5
1
2
0
1.1
55.2
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
72.1
platelet count
2
72.1
0
1.1
66.5
0
1.1
66.5
0
1.1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptic Ras GTPase activating protein 1
VGNC:12705
104001100
Macaque
synaptic Ras GTPase activating protein 1
717858
Mouse
MGI:3039785
240057
Rat
RGD:621090
192117
Dog
synaptic Ras GTPase activating protein 1
VGNC:47031
481742
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptic Ras GTPase activating protein 1
Macaque
synaptic Ras GTPase activating protein 1
Mouse
Rat
Dog
synaptic Ras GTPase activating protein 1
Publication Statistics
PubMed Score 198.48
PubMed score by year
PubTator Score 44.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title