Tbio QKI Protein quaking

Protein Summary

Description

RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q96PU8
• Q2I375
• Q5MJQ1
• Q969L9
• Q96EJ3
• Q96KA3
• Q96PU6
• Q96PU7
• Q9P0X6
• Q9P0X7
• Q9P0X8
• Q9P0X9
• Q9P0Y0
• Q9P0Y1
• Hqk

Gene Name

• QKI

Ensembl ID

• ENST00000275262
• ENSP00000275262
• ENSG00000112531
• ENST00000361195
• ENSP00000354867
• ENST00000361752
• ENSP00000355094
• ENST00000361758
• ENSP00000354951
• ENST00000392127
• ENSP00000375973
• ENST00000424802
• ENSP00000408382
• ENST00000453779
• ENSP00000408775

Symbol

• HKQ
• QK
• Hqk
• QK1
• QK3
• hqkI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	1
transcription factor perturbation	1
interacting protein	0.92
transcription factor binding site profile	0.89
kinase perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Protein Quaking

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Protein Quaking

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Protein Quaking

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.07   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 374   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.07   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0