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Tbio
NEDD4L
E3 ubiquitin-protein ligase NEDD4-like

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). This gene encodes a member of the Nedd4 family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256830
  • ENSP00000256830
  • ENSG00000049759
  • ENST00000356462
  • ENSP00000348847
  • ENST00000357895
  • ENSP00000350569
  • ENST00000382850
  • ENSP00000372301
  • ENST00000400345
  • ENSP00000383199
  • ENST00000431212
  • ENSP00000389406
  • ENST00000435432
  • ENSP00000393395
  • ENST00000456173
  • ENSP00000405440
  • ENST00000456986
  • ENSP00000411947
  • ENST00000586263
  • ENSP00000468546

Symbol
  • KIAA0439
  • NEDL3
  • RSP5
  • PVNH7
  • NEDD4-2
  • NEDD4.2
  • hNEDD4-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
0.98
transcription factor binding site profile
0.92
virus perturbation
0.92
transcription factor
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 514.39   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 514.39   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (440)
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.999997253
p_ni:  0.000002747
Score:  0.192
Data Source:  BioPlex,STRINGDB
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.99999444
p_ni:  0.00000556
Data Source:  BioPlex
WBP1
Tbio
Novelty:  1.24967974
p_int:  0.999982703
p_ni:  0.000017297
Score:  0.384
Data Source:  BioPlex,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
p_int:  0.999982044
p_ni:  0.000017956
Score:  0.329
Data Source:  BioPlex,STRINGDB
TMEM51
Tdark
Novelty:  0.54147214
p_int:  0.999944392
p_ni:  0.000055608
Data Source:  BioPlex
ILDR1
Tbio
Novelty:  0.05462229
p_int:  0.999942351
p_ni:  0.000057649
Score:  0.201
Data Source:  BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999940227
p_ni:  0.000059773
Score:  0.316
Data Source:  BioPlex,STRINGDB
KLF5
Tchem
Family:  TF
Novelty:  0.00384971
p_int:  0.999878953
p_ni:  0.000121047
Data Source:  BioPlex
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.999756253
p_ni:  0.000243747
Data Source:  BioPlex
SUSD6
Tbio
Novelty:  0.08836898
p_int:  0.999495716
p_ni:  0.000504284
Score:  0.235
Data Source:  BioPlex,STRINGDB
Pathways (37)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Budding and maturation of HIV virion
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Budding and maturation of HIV virion
Class I MHC mediated antigen processing & presentation
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
6
9
9
3.6
98.9
alkaline phosphatase measurement
2
4
3
9.2
92.6
serum alanine aminotransferase measurement
2
3
2
13
92.5
mathematical ability
4
3
4
89.4
aspartate aminotransferase measurement
2
2
1
7.8
81.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
9
3.6
98.9
alkaline phosphatase measurement
3
9.2
92.6
serum alanine aminotransferase measurement
2
13
92.5
mathematical ability
4
89.4
aspartate aminotransferase measurement
1
7.8
81.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
455443
Macaque
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
700282
Mouse
MGI:1933754
83814
Rat
RGD:735047
291553
Dog
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
VGNC:43721
476189
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Macaque
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Mouse
Rat
Dog
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Publication Statistics
PubMed Score 514.39
PubMed score by year
PubTator Score 174.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title