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Tbio
UHRF2
E3 ubiquitin-protein ligase UHRF2

Protein Summary
Description
E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131. This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276893
  • ENSP00000276893
  • ENSG00000147854
  • ENST00000468435
  • ENSP00000434182

Symbol
  • NIRF
  • RNF107
  • NIRF
  • URF2
  • RNF107
  • TDRD23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.91
molecular function
0.7
cell type or tissue
0.67
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.53   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.53   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
DPPA3
Tbio
Novelty:  0.03361743
p_int:  0.999999997
p_ni:  3e-9
Score:  0.281
Data Source:  BioPlex,STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.985
Data Source:  STRINGDB
ZNF131
Tbio
Family:  TF
Novelty:  0.18894578
Score:  0.946
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.938
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.902
Data Source:  STRINGDB
DNMT1
Tclin
Family:  Enzyme
Novelty:  0.00042336
Score:  0.885
Data Source:  STRINGDB
DNMT3B
Tchem
Family:  Epigenetic
Novelty:  0.00118766
Score:  0.763
Data Source:  STRINGDB
ZBTB38
Tbio
Family:  TF
Novelty:  0.05048192
Score:  0.759
Data Source:  STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.717
Data Source:  STRINGDB
CHTF18
Tbio
Novelty:  0.02470494
Score:  0.715
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription cofactors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HGNC
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
4
0
1.1
85.9
glycine measurement
1
1
1
82.6
hemoglobin measurement
2
2
2
72.7
hematocrit
2
2
2
71.3
sex hormone-binding globulin measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
85.9
glycine measurement
1
82.6
hemoglobin measurement
2
72.7
hematocrit
2
71.3
sex hormone-binding globulin measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like with PHD and ring finger domains 2
VGNC:8948
473164
Macaque
ubiquitin like with PHD and ring finger domains 2
715610
Mouse
MGI:1923718
109113
Rat
RGD:1309990
309331
Dog
ubiquitin like with PHD and ring finger domains 2
VGNC:48126
474702
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like with PHD and ring finger domains 2
Macaque
ubiquitin like with PHD and ring finger domains 2
Mouse
Rat
Dog
ubiquitin like with PHD and ring finger domains 2
Publication Statistics
PubMed Score 52.53
PubMed score by year
PubTator Score 38.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title