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Tbio
AQP10
Aquaporin-10

Protein Summary
Description
Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324978
  • ENSP00000318355
  • ENSG00000143595
  • ENST00000484864
  • ENSP00000420341

Symbol
  • AQPA_HUMAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.67
protein domain
0.58
tissue
0.55
metabolite
0.45
chemical
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.34   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.34   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
9
9
99.2
mean corpuscular hemoglobin concentration
2
2
2
89.3
mean corpuscular volume
1
2
2
78.4
1
1
0
1.1
70.5
serum non-albumin protein measurement
2
3
3
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
9
99.2
mean corpuscular hemoglobin concentration
2
89.3
mean corpuscular volume
2
78.4
0
1.1
70.5
serum non-albumin protein measurement
3
68
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aquaporin 10
VGNC:388
739880
Macaque
aquaporin 10
697815
Cow
aquaporin 10
VGNC:26044
785782
Pig
aquaporin 10
100144620
Opossum
aquaporin 10
100020418
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aquaporin 10
Macaque
aquaporin 10
Cow
aquaporin 10
Pig
aquaporin 10
Opossum
aquaporin 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96PS8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (13)
1 – 10 of 13
AQP8
Tbio
Novelty:  0.00613662
Score:  0.933
Data Source:  STRINGDB
AQP6
Tbio
Novelty:  0.02315464
Score:  0.906
Data Source:  STRINGDB
MIP
Tbio
Novelty:  0.00299543
Score:  0.9
Data Source:  STRINGDB
AQP12A
Tbio
Novelty:  0.04258853
Score:  0.886
Data Source:  STRINGDB
AQP5
Tbio
Novelty:  0.00198806
Score:  0.882
Data Source:  STRINGDB
AQP11
Tbio
Novelty:  0.0229197
Score:  0.826
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.749
Data Source:  STRINGDB
SLC10A4
Tbio
Family:  Transporter
Novelty:  0.1560734
Score:  0.515
Data Source:  STRINGDB
GPR68
Tchem
Family:  GPCR
Novelty:  0.01309603
Score:  0.503
Data Source:  STRINGDB
GK
Tbio
Family:  Kinase
Novelty:  0.00617547
Score:  0.502
Data Source:  STRINGDB
Publication Statistics
PubMed Score  24.34

PubMed score by year
PubTator Score  15.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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