Protein Summary
Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]
- ENST00000324978
- ENSP00000318355
- ENSG00000143595
- ENST00000484864
- ENSP00000420341
- AQPA_HUMAN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.67 | ||
protein domain | 0.58 | ||
tissue | 0.55 | ||
metabolite | 0.45 | ||
chemical | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.34 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.34 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (13)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Passive transport by Aquaporins | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aquaporin-mediated transport | ||||
Passive transport by Aquaporins | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (3)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Experiment (EXP) | Reactome | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 3 | 9 | 9 | 99.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 89.3 | |||||
mean corpuscular volume | 1 | 2 | 2 | 78.4 | |||||
1 | 1 | 0 | 1.1 | 70.5 | |||||
serum non-albumin protein measurement | 2 | 3 | 3 | 68 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 9 | 99.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 89.3 | |||||
mean corpuscular volume | 2 | 78.4 | |||||
0 | 1.1 | 70.5 | |||||
serum non-albumin protein measurement | 3 | 68 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aquaporin 10 | VGNC:388 | 739880 | |||||
Macaque | aquaporin 10 | 697815 | ||||||
Cow | aquaporin 10 | VGNC:26044 | 785782 | |||||
Pig | aquaporin 10 | 100144620 | ||||||
Opossum | aquaporin 10 | 100020418 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aquaporin 10 | |||||
Macaque | aquaporin 10 | |||||
Cow | aquaporin 10 | |||||
Pig | aquaporin 10 | |||||
Opossum | aquaporin 10 | |||||
Publication Statistics
PubMed Score 24.34
PubMed score by year
PubTator Score 15.35
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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