Protein Classes
Protein Summary
Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]
- ENST00000324978
- ENSP00000318355
- ENSG00000143595
- ENST00000484864
- ENSP00000420341
- AQPA_HUMAN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.67 | ||
protein domain | 0.58 | ||
tissue | 0.55 | ||
metabolite | 0.45 | ||
chemical | 0.44 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.34 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.34 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 3 | 9 | 9 | 99.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 89.3 | |||||
mean corpuscular volume | 1 | 2 | 2 | 78.4 | |||||
1 | 1 | 0 | 1.1 | 70.5 | |||||
serum non-albumin protein measurement | 2 | 3 | 3 | 68 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 9 | 99.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 89.3 | |||||
mean corpuscular volume | 2 | 78.4 | |||||
0 | 1.1 | 70.5 | |||||
serum non-albumin protein measurement | 3 | 68 | |||||
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aquaporin 10 | VGNC:388 | 739880 | |||||
Macaque | aquaporin 10 | 697815 | ||||||
Cow | aquaporin 10 | VGNC:26044 | 785782 | |||||
Pig | aquaporin 10 | 100144620 | ||||||
Opossum | aquaporin 10 | 100020418 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aquaporin 10 | |||||
Macaque | aquaporin 10 | |||||
Cow | aquaporin 10 | |||||
Pig | aquaporin 10 | |||||
Opossum | aquaporin 10 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Passive transport by Aquaporins | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aquaporin-mediated transport | ||||
Passive transport by Aquaporins | ||||
Transport of small molecules | ||||
Gene Ontology Terms (7)
Functions (3)
Components (2)
Processes (2)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Experiment (EXP) | Reactome | |||
Protein-Protein Interactions (13)
1 – 10 of 13
AQP8
Novelty: 0.00613662
Score: 0.933
Data Source: STRINGDB
AQP6
Novelty: 0.02315464
Score: 0.906
Data Source: STRINGDB
MIP
Novelty: 0.00299543
Score: 0.9
Data Source: STRINGDB
AQP12A
Novelty: 0.04258853
Score: 0.886
Data Source: STRINGDB
AQP5
Novelty: 0.00198806
Score: 0.882
Data Source: STRINGDB
AQP11
Novelty: 0.0229197
Score: 0.826
Data Source: STRINGDB
GATA1
Family: TF
Novelty: 0.00077901
Score: 0.749
Data Source: STRINGDB
SLC10A4
Family: Transporter
Novelty: 0.1560734
Score: 0.515
Data Source: STRINGDB
GPR68
Family: GPCR
Novelty: 0.01309603
Score: 0.503
Data Source: STRINGDB
GK
Family: Kinase
Novelty: 0.00617547
Score: 0.502
Data Source: STRINGDB
Publication Statistics
PubMed Score 24.34
PubMed score by year
PubTator Score 15.35
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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GWAS Trait
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