Tbio SORCS2 VPS10 domain-containing receptor SorCS2

Protein Summary

Description

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96PQ0
• Q9P2L7

Gene Name

• SORCS2

Ensembl ID

• ENST00000507866
• ENSP00000422185
• ENSG00000184985

Symbol

• KIAA1329

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
gene perturbation	0.78
disease	0.69
phenotype	0.66
tissue sample	0.66

Protein Classes

PANTHER Classes

Protein / Transporter / Vps10 Domain-containing Receptor Sorcs2

Protein / Receptor / Vps10 Domain-containing Receptor Sorcs2

DTO Classes

Protein / Transporter / Vps10 Domain-containing Receptor Sorcs2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.91   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.91   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0