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Tbio
GBP5
Guanylate-binding protein 5

Protein Summary
Description
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370459
  • ENSP00000359488
  • ENSG00000154451

Symbol
  • GBP-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
molecular function
0.93
cell type or tissue
0.74
cell line
0.7
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.02   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.02   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (192)
1 – 10 of 192
SLC22A16
Tbio
Family: Transporter
Novelty: 0.03379851
p_int: 0.999999979
p_ni: 7e-9
p_wrong: 1.4e-8
Score: 0.313
Data Source: BioPlex,STRINGDB
GBP1
Tbio
Novelty: 0.00634662
p_int: 0.999999834
p_ni: 1.22e-7
p_wrong: 4.4e-8
Score: 0.826
Data Source: BioPlex,STRINGDB
CPEB1
Tbio
Novelty: 0.00444378
p_int: 0.999976175
p_ni: 0.000023815
p_wrong: 1e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
ACSM1
Tbio
Family: Enzyme
Novelty: 0.01901085
p_int: 0.999815863
p_ni: 0.000184131
p_wrong: 6e-9
Score: 0.829
Data Source: BioPlex,STRINGDB
C1orf159
Tdark
Novelty: 1.78509526
p_int: 0.963083589
p_ni: 0.010217201
p_wrong: 0.02669921
Score: 0.309
Data Source: BioPlex,STRINGDB
APOL2
Tbio
Novelty: 0.06076255
p_int: 0.934902466
p_ni: 0.062035741
p_wrong: 0.003061793
Score: 0.259
Data Source: BioPlex,STRINGDB
SURF1
Tbio
Novelty: 0.00717605
p_int: 0.913617707
p_ni: 0.085113319
p_wrong: 0.001268974
Score: 0.19
Data Source: BioPlex,STRINGDB
EPHA4
Tchem
Family: Kinase
Novelty: 0.00321698
p_int: 0.881629464
p_ni: 0.118370534
p_wrong: 2e-9
Data Source: BioPlex
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
IRF1
Tbio
Family: TF
Novelty: 0.00099983
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.02

PubMed score by year
PubTator Score  11.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer