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Tchem
ADCY10
Adenylate cyclase type 10

Protein Summary
Description
Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988). The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367848
  • ENSP00000356822
  • ENSG00000143199
  • ENST00000367851
  • ENSP00000356825
  • ENST00000545172
  • ENSP00000441992

Symbol
  • SAC
  • SAC
  • HCA2
  • SACI
  • Sacy
  • hsAC
  • HEL-S-7a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.73
cellular component
0.65
cell type or tissue
0.59
biological process
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2329.8   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2329.8   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (243)
1 – 10 of 243
PDE4A
Tclin
Family:  Enzyme
Novelty:  0.00067574
Score:  0.862
Data Source:  STRINGDB
CHEK2
Tchem
Family:  Kinase
Novelty:  0.00068355
Score:  0.85
Data Source:  STRINGDB
PDE2A
Tclin
Family:  Enzyme
Novelty:  0.00862513
Score:  0.84
Data Source:  STRINGDB
PDE4B
Tclin
Family:  Enzyme
Novelty:  0.00528932
Score:  0.837
Data Source:  STRINGDB
PDE4D
Tclin
Family:  Enzyme
Novelty:  0.00339482
Score:  0.822
Data Source:  STRINGDB
PDE5A
Tclin
Family:  Enzyme
Novelty:  0.00032205
Score:  0.817
Data Source:  STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
Score:  0.815
Data Source:  STRINGDB
PDE4C
Tclin
Family:  Enzyme
Novelty:  0.03645306
Score:  0.813
Data Source:  STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
Score:  0.811
Data Source:  STRINGDB
PDE7A
Tclin
Family:  Enzyme
Novelty:  0.00872596
Score:  0.808
Data Source:  STRINGDB
Pathways (30)
Hedgehog 'off' state (R-HSA-5610787)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hedgehog 'off' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Hedgehog 'off' state
Signal Transduction
Signaling by Hedgehog
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 10
VGNC:34
469570
Macaque
adenylate cyclase 10
698566
Mouse
MGI:2660854
271639
Rat
RGD:708450
59320
Dog
adenylate cyclase 10
VGNC:53325
480087
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 10
Macaque
adenylate cyclase 10
Mouse
Rat
Dog
adenylate cyclase 10
Publication Statistics
PubMed Score 2329.80
PubMed score by year
PubTator Score 89.21
PubTator score by year