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Tbio
RCHY1
RING finger and CHY zinc finger domain-containing protein 1

Protein Summary
Description
Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324439
  • ENSP00000321239
  • ENSG00000163743
  • ENST00000380840
  • ENSP00000370220
  • ENST00000505105
  • ENSP00000424631
  • ENST00000507014
  • ENSP00000424472
  • ENST00000512706
  • ENSP00000423976
  • ENST00000513257
  • ENSP00000421084

Symbol
  • ARNIP
  • CHIMP
  • PIRH2
  • RNF199
  • ZNF363
  • ZCHY
  • ARNIP
  • CHIMP
  • PIRH2
  • RNF199
  • ZNF363
  • PRO1996
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
microRNA
0.81
histone modification site profile
0.76
protein domain
0.73
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.83   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.83   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (355)
UBASH3B
Tbio
Novelty:  0.02155898
p_int:  0.999999995
p_ni:  5e-9
Score:  0.543
Data Source:  BioPlex,STRINGDB
ALAS1
Tclin
Family:  Enzyme
Novelty:  0.00965779
p_int:  0.999995947
p_ni:  0.000004053
Score:  0.345
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.989
Data Source:  STRINGDB
HUWE1
Tbio
Family:  Enzyme
Novelty:  0.01104129
Score:  0.967
Data Source:  STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.961
Data Source:  STRINGDB
TP73
Tbio
Family:  TF
Novelty:  0.00667737
Score:  0.957
Data Source:  STRINGDB
KLHL41
Tbio
Novelty:  0.03973182
Score:  0.954
Data Source:  STRINGDB
POLH
Tchem
Family:  Enzyme
Novelty:  0.00458533
Score:  0.952
Data Source:  Reactome,STRINGDB
WWP1
Tbio
Family:  Enzyme
Novelty:  0.01407874
Score:  0.946
Data Source:  STRINGDB
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
DNA Damage Bypass
DNA Repair
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
79.2
1
1
0
1.2
49.5
2
2
2
49.4
self reported educational attainment
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
79.2
0
1.2
49.5
2
49.4
self reported educational attainment
1
2.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger and CHY zinc finger domain containing 1
VGNC:6479
461248
Macaque
ring finger and CHY zinc finger domain containing 1
701580
Mouse
MGI:1915348
68098
Rat
RGD:1359180
289508
Dog
ring finger and CHY zinc finger domain containing 1
VGNC:45443
612746
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger and CHY zinc finger domain containing 1
Macaque
ring finger and CHY zinc finger domain containing 1
Mouse
Rat
Dog
ring finger and CHY zinc finger domain containing 1
Publication Statistics
PubMed Score 58.83
PubMed score by year
PubTator Score 134.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title