Tbio RCHY1 RING finger and CHY zinc finger domain-containing protein 1

Protein Summary

Description

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q96PM5
• B3KRG3
• C7E541
• C7E542
• C7E543
• D3YRV2
• E7EMC8
• E7ETW5
• J3KPI0
• Q2KN33
• Q59GN7
• Q86X26
• Q96PR5

Gene Name

• RCHY1

Ensembl ID

• ENST00000324439
• ENSP00000321239
• ENSG00000163743
• ENST00000380840
• ENSP00000370220
• ENST00000505105
• ENSP00000424631
• ENST00000507014
• ENSP00000424472
• ENST00000512706
• ENSP00000423976
• ENST00000513257
• ENSP00000421084

Symbol

• ARNIP
• CHIMP
• PIRH2
• RNF199
• ZNF363
• ZCHY
• ARNIP
• CHIMP
• PIRH2
• RNF199
• ZNF363
• PRO1996

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.87
microRNA	0.81
histone modification site profile	0.76
protein domain	0.73
cellular component	0.65

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Ring Finger And Chy Zinc Finger Domain-containing Protein 1

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Ring Finger And Chy Zinc Finger Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.18   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.18   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0