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Tbio
ERMAP
Erythroid membrane-associated protein

Protein Summary
Description
Possible role as a cell-adhesion or receptor molecule of erythroid cells. The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. Polymorphisms in this gene are responsible for the Scianna/Radin blood group system. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372514
  • ENSP00000361592
  • ENSG00000164010
  • ENST00000372517
  • ENSP00000361595

Symbol
  • RD
  • SC
  • RD
  • SC
  • BTN5
  • PRO2801
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.92
histone modification site profile
0.8
small molecule perturbation
0.7
microRNA
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.09   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.09   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (41)
1 – 10 of 41
MECOM
Tbio
Family:  TF; Epigenetic
Novelty:  0.00500501
p_int:  0.999997911
p_ni:  0.000002069
p_wrong:  2e-8
Score:  0.266
Data Source:  BioPlex,STRINGDB
FAM199X
Tdark
Novelty:  1.32503264
p_int:  0.999883321
p_ni:  0.000116674
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
DOCK4
Tbio
Novelty:  0.02356655
p_int:  0.99945718
p_ni:  0.000542818
p_wrong:  2e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
USP34
Tbio
Family:  Enzyme
Novelty:  0.16444192
p_int:  0.997302515
p_ni:  0.002697485
Score:  0.208
Data Source:  BioPlex,STRINGDB
ELMO2
Tbio
Novelty:  0.04258272
p_int:  0.994858391
p_ni:  0.005135329
p_wrong:  0.00000628
Data Source:  BioPlex
CWC22
Tbio
Novelty:  0.027689
p_int:  0.994802681
p_ni:  0.005197319
Score:  0.158
Data Source:  BioPlex,STRINGDB
AP3B1
Tbio
Novelty:  0.03117931
p_int:  0.988221178
p_ni:  0.011778822
Data Source:  BioPlex
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.975579664
p_ni:  0.024420336
Data Source:  BioPlex
GEMIN2
Tbio
Novelty:  0.02072868
p_int:  0.952969794
p_ni:  0.047017096
p_wrong:  0.00001311
Data Source:  BioPlex
AKAP11
Tbio
Family:  Enzyme
Novelty:  0.0685826
p_int:  0.914272706
p_ni:  0.085727294
Data Source:  BioPlex
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
1
1
67.3
red blood cell distribution width
1
1
1
50.6
calcium measurement
1
1
1
49.5
leukocyte count
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
67.3
red blood cell distribution width
1
50.6
calcium measurement
1
49.5
leukocyte count
1
48.5
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
erythroblast membrane associated protein
VGNC:6800
469304
Mouse
MGI:1349816
27028
Rat
RGD:1309996
298485
Dog
erythroblast membrane associated protein (Scianna blood group)
VGNC:54204
482439
Horse
erythroblast membrane associated protein (Scianna blood group)
100067234
Species
Name
OMA
EggNOG
Inparanoid
Chimp
erythroblast membrane associated protein
Mouse
Rat
Dog
erythroblast membrane associated protein (Scianna blood group)
Horse
erythroblast membrane associated protein (Scianna blood group)
Publication Statistics
PubMed Score 28.09
PubMed score by year
PubTator Score 11.50
PubTator score by year